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- W2549913054 abstract "Purpose: To develop an Aceclofenac transdermal gel with a capability for topical drug delivery and The purpose of this study is to obtain scientific information regarding health hazards that may result from a acute dermal exposure to the agricultural chemical for providing the basis of laying down the measure of safety protection in application. Methods: Aceclofenac gel formulations, incorporating various permeation enhancers, were prepared using carbomer as a gelling agent. The formulations were examined for their in vitro characteristics including viscosity, pH and drug release as well as in-vivo pharmacological activities. Results: The formulations containing 5 % of either Propylene glycol as permeation enhancers gave drug release patterns comparable to that of the reference product. Propanol increased the apparent viscosity of the test gels to the same extent as that of the reference. Drug release from the formulations fitted best to the Higuchi model. A significant in vivo analgesic effect was produced by the test formulations and the effect was superior to that obtained with the reference product. Conclusion: Aceclofenac gel preparations containing propylene glycol respectively, exhibited pronounced analgesic activity and could be further developed for topical delivery of Aceclofenac." @default.
- W2549913054 created "2016-11-30" @default.
- W2549913054 creator A5073977096 @default.
- W2549913054 date "2015-01-01" @default.
- W2549913054 modified "2023-09-27" @default.
- W2549913054 title "In-Vivo Acute Dermal Toxicity Study of Formulations on Rabbits" @default.
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