FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549962131> ?p ?o ?g. }

• W2549962131 endingPage "208" @default.
• W2549962131 startingPage "201" @default.
• W2549962131 abstract "The promoter polymorphisms of tumour necrosis factor-α (TNF-α) and intronic Lymphotoxin-α (LTα) have been implicated as genetic risk factors for systemic lupus erythematosus (SLE) in various ethnic groups. The aim of this study was to investigate an impact of TNF-α (−308G/A; 238G/A) and LTα (+252A/G) gene polymorphisms in disease susceptibility among Indian 200 SLE patients along with 201 healthy controls. The gene polymorphisms were studied by using direct DNA sequencing and Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) methods. Serum levels were measured by multiplex assay. Allelic frequencies of TNF-α −308A (OR = 2.3, p = 0.0001, Pc = 0.0003) and LTα +252G (OR = 2.1, p < 0.0001, Pc < 0.001) were significantly higher in SLE patients. Frequency of haplotype-AGG was found to be higher in patients than controls (OR = 12.2, p = 0.0050). Serum levels of TNF-α and LTα also were found to be significantly higher in patients showing variant alleles. TNF-α −308G/A + A/A genotypes (p < 0.01) and LTα +252 A/G + G/G genotypes (p < 0.02) were significantly associated with renal disorders and haematological manifestations. SLE patients with −308G/A + A/A genotypes showed higher prevalence of anti-dsDNA antibodies (OR = 3.9, p = 0.0014, Pc = 0.0098) and anti-Sm antibodies (OR = 4.1, p = 0.0002, Pc = 0.0014). The present study suggests TNF-α −308A and LTα +252G as risk alleles for disease susceptibility associated with higher serum levels of TNF-α and LTα and concomitant discrete clinical features among Indian SLE patients." @default.
• W2549962131 created "2016-11-30" @default.
• W2549962131 creator A5017913326 @default.
• W2549962131 creator A5031782697 @default.
• W2549962131 creator A5036602580 @default.
• W2549962131 creator A5051383434 @default.
• W2549962131 creator A5076877409 @default.
• W2549962131 creator A5078058553 @default.
• W2549962131 date "2017-02-01" @default.
• W2549962131 modified "2023-10-16" @default.
• W2549962131 title "Impact of TNF-α and LTα gene polymorphisms on genetic susceptibility in Indian SLE patients" @default.
• W2549962131 cites W1510756896 @default.
• W2549962131 cites W1587947414 @default.
• W2549962131 cites W1594609332 @default.
• W2549962131 cites W1964092946 @default.
• W2549962131 cites W1980799869 @default.
• W2549962131 cites W1983952821 @default.
• W2549962131 cites W1989783048 @default.
• W2549962131 cites W1991060602 @default.
• W2549962131 cites W2021274912 @default.
• W2549962131 cites W2028582979 @default.
• W2549962131 cites W2029255228 @default.
• W2549962131 cites W2031357644 @default.
• W2549962131 cites W2034583127 @default.
• W2549962131 cites W2034844280 @default.
• W2549962131 cites W2038555149 @default.
• W2549962131 cites W2038697192 @default.
• W2549962131 cites W2041712515 @default.
• W2549962131 cites W2046088649 @default.
• W2549962131 cites W2067503899 @default.
• W2549962131 cites W2070527591 @default.
• W2549962131 cites W2072681359 @default.
• W2549962131 cites W2075659566 @default.
• W2549962131 cites W2078178190 @default.
• W2549962131 cites W2091842850 @default.
• W2549962131 cites W2094304782 @default.
• W2549962131 cites W2098149456 @default.
• W2549962131 cites W2103301773 @default.
• W2549962131 cites W2121171258 @default.
• W2549962131 cites W2130669297 @default.
• W2549962131 cites W2130749110 @default.
• W2549962131 cites W2133589818 @default.
• W2549962131 cites W2134193741 @default.
• W2549962131 cites W2159571049 @default.
• W2549962131 cites W2333707811 @default.
• W2549962131 cites W2335610221 @default.
• W2549962131 doi "https://doi.org/10.1016/j.humimm.2016.11.002" @default.
• W2549962131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27838362" @default.
• W2549962131 hasPublicationYear "2017" @default.
• W2549962131 type Work @default.
• W2549962131 sameAs 2549962131 @default.
• W2549962131 citedByCount "13" @default.
• W2549962131 countsByYear W25499621312018 @default.
• W2549962131 countsByYear W25499621312019 @default.
• W2549962131 countsByYear W25499621312020 @default.
• W2549962131 countsByYear W25499621312022 @default.
• W2549962131 countsByYear W25499621312023 @default.
• W2549962131 crossrefType "journal-article" @default.
• W2549962131 hasAuthorship W2549962131A5017913326 @default.
• W2549962131 hasAuthorship W2549962131A5031782697 @default.
• W2549962131 hasAuthorship W2549962131A5036602580 @default.
• W2549962131 hasAuthorship W2549962131A5051383434 @default.
• W2549962131 hasAuthorship W2549962131A5076877409 @default.
• W2549962131 hasAuthorship W2549962131A5078058553 @default.
• W2549962131 hasConcept C104317684 @default.
• W2549962131 hasConcept C126322002 @default.
• W2549962131 hasConcept C135763542 @default.
• W2549962131 hasConcept C159654299 @default.
• W2549962131 hasConcept C168007829 @default.
• W2549962131 hasConcept C17991360 @default.
• W2549962131 hasConcept C180754005 @default.
• W2549962131 hasConcept C197754878 @default.
• W2549962131 hasConcept C203014093 @default.
• W2549962131 hasConcept C37463918 @default.
• W2549962131 hasConcept C49105822 @default.
• W2549962131 hasConcept C54355233 @default.
• W2549962131 hasConcept C71924100 @default.
• W2549962131 hasConcept C86803240 @default.
• W2549962131 hasConceptScore W2549962131C104317684 @default.
• W2549962131 hasConceptScore W2549962131C126322002 @default.
• W2549962131 hasConceptScore W2549962131C135763542 @default.
• W2549962131 hasConceptScore W2549962131C159654299 @default.
• W2549962131 hasConceptScore W2549962131C168007829 @default.
• W2549962131 hasConceptScore W2549962131C17991360 @default.
• W2549962131 hasConceptScore W2549962131C180754005 @default.
• W2549962131 hasConceptScore W2549962131C197754878 @default.
• W2549962131 hasConceptScore W2549962131C203014093 @default.
• W2549962131 hasConceptScore W2549962131C37463918 @default.
• W2549962131 hasConceptScore W2549962131C49105822 @default.
• W2549962131 hasConceptScore W2549962131C54355233 @default.
• W2549962131 hasConceptScore W2549962131C71924100 @default.
• W2549962131 hasConceptScore W2549962131C86803240 @default.
• W2549962131 hasFunder F4320320721 @default.
• W2549962131 hasIssue "2" @default.
• W2549962131 hasLocation W25499621311 @default.
• W2549962131 hasLocation W25499621312 @default.
• W2549962131 hasOpenAccess W2549962131 @default.
• W2549962131 hasPrimaryLocation W25499621311 @default.

• next