FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2549968211> ?p ?o ?g. }

• W2549968211 abstract "Vibrio cholerae has caused seven cholera pandemics since 1817, imposing terror on much of the world, but bacterial strains are currently only available for the sixth and seventh pandemics. The El Tor biotype seventh pandemic began in 1961 in Indonesia, but did not originate directly from the classical biotype sixth-pandemic strain. Previous studies focused mainly on the spread of the seventh pandemic after 1970. Here, we analyze in unprecedented detail the origin, evolution, and transition to pandemicity of the seventh-pandemic strain. We used high-resolution comparative genomic analysis of strains collected from 1930 to 1964, covering the evolution from the first available El Tor biotype strain to the start of the seventh pandemic. We define six stages leading to the pandemic strain and reveal all key events. The seventh pandemic originated from a nonpathogenic strain in the Middle East, first observed in 1897. It subsequently underwent explosive diversification, including the spawning of the pandemic lineage. This rapid diversification suggests that, when first observed, the strain had only recently arrived in the Middle East, possibly from the Asian homeland of cholera. The lineage migrated to Makassar, Indonesia, where it gained the important virulence-associated elements Vibrio seventh pandemic island I (VSP-I), VSP-II, and El Tor type cholera toxin prophage by 1954, and it then became pandemic in 1961 after only 12 additional mutations. Our data indicate that specific niches in the Middle East and Makassar were important in generating the pandemic strain by providing gene sources and the driving forces for genetic events." @default.
• W2549968211 created "2016-11-30" @default.
• W2549968211 creator A5017371998 @default.
• W2549968211 creator A5038351828 @default.
• W2549968211 creator A5041171716 @default.
• W2549968211 creator A5042293438 @default.
• W2549968211 creator A5048826252 @default.
• W2549968211 creator A5059417921 @default.
• W2549968211 creator A5073216396 @default.
• W2549968211 creator A5084809554 @default.
• W2549968211 creator A5088825158 @default.
• W2549968211 date "2016-11-14" @default.
• W2549968211 modified "2023-10-16" @default.
• W2549968211 title "Origins of the current seventh cholera pandemic" @default.
• W2549968211 cites W1464493286 @default.
• W2549968211 cites W1487432871 @default.
• W2549968211 cites W1579864754 @default.
• W2549968211 cites W1630914478 @default.
• W2549968211 cites W1707856041 @default.
• W2549968211 cites W1941363222 @default.
• W2549968211 cites W1951598774 @default.
• W2549968211 cites W1965897416 @default.
• W2549968211 cites W1989752256 @default.
• W2549968211 cites W1990473825 @default.
• W2549968211 cites W1992256609 @default.
• W2549968211 cites W1997337736 @default.
• W2549968211 cites W2003841579 @default.
• W2549968211 cites W2004693846 @default.
• W2549968211 cites W2008821578 @default.
• W2549968211 cites W2021364411 @default.
• W2549968211 cites W2030308865 @default.
• W2549968211 cites W2032716569 @default.
• W2549968211 cites W2052558548 @default.
• W2549968211 cites W2065214355 @default.
• W2549968211 cites W2066526441 @default.
• W2549968211 cites W2067320696 @default.
• W2549968211 cites W2086782500 @default.
• W2549968211 cites W2094939159 @default.
• W2549968211 cites W2110542485 @default.
• W2549968211 cites W2111409242 @default.
• W2549968211 cites W2121683435 @default.
• W2549968211 cites W2123251060 @default.
• W2549968211 cites W2129883447 @default.
• W2549968211 cites W2138016371 @default.
• W2549968211 cites W2139782018 @default.
• W2549968211 cites W2142941796 @default.
• W2549968211 cites W2156273926 @default.
• W2549968211 cites W2159393451 @default.
• W2549968211 cites W2166951427 @default.
• W2549968211 cites W2168696662 @default.
• W2549968211 cites W2170063833 @default.
• W2549968211 cites W2172009274 @default.
• W2549968211 cites W2246868198 @default.
• W2549968211 cites W2324339247 @default.
• W2549968211 cites W2399944702 @default.
• W2549968211 cites W2415519521 @default.
• W2549968211 cites W2425500421 @default.
• W2549968211 cites W29176823 @default.
• W2549968211 cites W4211176329 @default.
• W2549968211 cites W4211185542 @default.
• W2549968211 cites W4230223778 @default.
• W2549968211 cites W4302324990 @default.
• W2549968211 cites W4307246 @default.
• W2549968211 cites W83168138 @default.
• W2549968211 cites W93895971 @default.
• W2549968211 cites W983505223 @default.
• W2549968211 doi "https://doi.org/10.1073/pnas.1608732113" @default.
• W2549968211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5137724" @default.
• W2549968211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27849586" @default.
• W2549968211 hasPublicationYear "2016" @default.
• W2549968211 type Work @default.
• W2549968211 sameAs 2549968211 @default.
• W2549968211 citedByCount "136" @default.
• W2549968211 countsByYear W25499682112017 @default.
• W2549968211 countsByYear W25499682112018 @default.
• W2549968211 countsByYear W25499682112019 @default.
• W2549968211 countsByYear W25499682112020 @default.
• W2549968211 countsByYear W25499682112021 @default.
• W2549968211 countsByYear W25499682112022 @default.
• W2549968211 countsByYear W25499682112023 @default.
• W2549968211 crossrefType "journal-article" @default.
• W2549968211 hasAuthorship W2549968211A5017371998 @default.
• W2549968211 hasAuthorship W2549968211A5038351828 @default.
• W2549968211 hasAuthorship W2549968211A5041171716 @default.
• W2549968211 hasAuthorship W2549968211A5042293438 @default.
• W2549968211 hasAuthorship W2549968211A5048826252 @default.
• W2549968211 hasAuthorship W2549968211A5059417921 @default.
• W2549968211 hasAuthorship W2549968211A5073216396 @default.
• W2549968211 hasAuthorship W2549968211A5084809554 @default.
• W2549968211 hasAuthorship W2549968211A5088825158 @default.
• W2549968211 hasBestOaLocation W25499682111 @default.
• W2549968211 hasConcept C104317684 @default.
• W2549968211 hasConcept C105702510 @default.
• W2549968211 hasConcept C142724271 @default.
• W2549968211 hasConcept C159047783 @default.
• W2549968211 hasConcept C205649164 @default.
• W2549968211 hasConcept C2776441376 @default.
• W2549968211 hasConcept C2776817793 @default.
• W2549968211 hasConcept C2778022156 @default.
• W2549968211 hasConcept C2778643871 @default.

• next