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• W2550081472 abstract "A series of nitric oxide (NO) donating derivatives of hederacolchiside A1 bearing triterpenoid saponin motif were designed, synthesized and evaluated for their anticancer activity. All of the tested furoxan-based NO releasing compounds showed significant proliferation inhibitory activities. Especially compound 6a exhibited strong cytotoxicity (IC50=1.6-6.5μM) against four human tumor cell lines (SMMC-7721, NCI-H460, U251, HCT-116) in vitro and the highest level of NO releasing. Furthermore, compound 6a was revealed low acute toxicity to mice and weak haemolytic activity with potent tumor growth inhibition against mice H22 hepatocellular cells in vivo (51.5%)." @default.
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• W2550081472 date "2017-01-01" @default.
• W2550081472 modified "2023-09-27" @default.
• W2550081472 title "Nitric oxide-donating derivatives of hederacolchiside A 1 : Synthesis and biological evaluation in vitro and in vivo as potential anticancer agents" @default.
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• W2550081472 doi "https://doi.org/10.1016/j.bmcl.2016.11.021" @default.
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