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• W2550200059 abstract "<h3>Background</h3> Little is known about tumor-necrosis-factor-alpha-inhibitor (TNFi) treatment outcomes in Ankylosing Spondylitis (AS) vs. non-radiographic axial spondyloartrhitis (nr-axSpA). <h3>Objectives</h3> To compare baseline disease activity and treatment outcomes in biologic naïve patients with AS and nr-axSpA, who initiate TNFi treatment in clinical practice taking potential confounders into consideration. <h3>Methods</h3> We performed an observational cohort study based on prospectively registered data in the nationwide Danish quality registry, DANBIO, including baseline and 3–6 months9 follow-up markers of disease activity (visual analogue score (VAS) global disease, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), BAS metrology index (BASMI) and serum C-reactive protein (CRP)). Treatment response was defined as either a 50% or a 20 mm reduction in BASDAI after 3–6 mths treatment. We used Kaplan-Meier plots, Cox and logistic regression analyses to study the impact of diagnosis (AS vs. nr-axSpA) and potential confounders (gender, age, start year, HLA-B27, disease duration, TNFi type, smoking, baseline disease activity) on TNFi adherence and response. Numbers are medians (IQR) unless otherwise stated. <h3>Results</h3> We identified 1,250 TNFi naïve patients in DANBIO with axSpA according to the treating physician. Of these, 50% had AS, 28% nr-axSpA and 21% lacked X-rays of sacroiliac joints. Baseline demographics and disease activity differed in nr-axSpA vs. AS (Table). Response rates were similar, but treatment adherence was poorer in nr-axSpA than in AS (univariate, Table). In confounder adjusted analyses, axSpA sub-diagnosis was not associated with response rates or treatment adherence. However, HLA-B27 positivity was associated with better treatment adherence (HLA-B27 neg/pos, nr-axSpA: HR 1.74 (1.29–2.36), AS: HR 2.04 (1.53–2.71.), both p<0.0001) (Figure) and higher response rates (nr-axSpA: 30%/55%, AS: 29%/54%, univariate, both p<0.05). Similar results for HLA-B27 were found in confounder-adjusted analyses. <h3>Conclusions</h3> In this nationwide cohort, patients with nr-axSpA had higher subjective disease activity at the start of the first TNFi treatment but had similar confounder adjusted treatment adherences and response as AS pts. HLA-B27 positive pts had better outcomes irrespective of axSpA sub-diagnosis. <h3>Disclosure of Interest</h3> B. Glintborg: None declared, I. Juul Sørensen: None declared, M. Østergaard: None declared, A. A. Mahamoud: None declared, N. S. Krogh: None declared, L. Andersen: None declared, J. Raun: None declared, O. Hendricks: None declared, M. Kowalski: None declared, L. Danielsen: None declared, S. Christensen: None declared, N. al Chaer: None declared, R. Pelck: None declared, H. Nordin: None declared, J. Pedersen: None declared, D. Kraus: None declared, I. Jensen Hansen: None declared, J. Espesen: None declared, A. Schlemmer: None declared, A. Loft Speakers bureau: MSD, L. Salomonsen: None declared, L. Dreyer: None declared, M. Hetland: None declared" @default.
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• W2550200059 date "2016-06-01" @default.
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• W2550200059 title "SAT0371 Hla-B27 Status Is Associated with tnfα Inhibitor Treatment Outcomes in Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis – Observational Cohort Study from The Nationwide Danbio Registry" @default.
• W2550200059 doi "https://doi.org/10.1136/annrheumdis-2016-eular.2098" @default.
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