Matches in SemOpenAlex for { <https://semopenalex.org/work/W2550232145> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2550232145 abstract "Introduction: Rho-kinases (ROCK) serve as a point of convergence of various signalling cascades in the pathogenesis of pulmonary arterial hypertension (PAH) and plays a role in vasoconstriction induced by endothelin. We assessed the effect of the ROCK inhibitor Y-27632 in monocrotaline (MCT)-induced PAH in rats, an experimental model utilized to mimic clinical features of PAH. Methods and results: Male Wistar rats were randomized into three groups: sham (CTRL, n=6); MCT (n=15); MCT+ Y-27632 (n=15). Two weeks after a single subcutaneous (s.c.) injection of monocrotaline (MCT, 60 mg/Kg), rats received a once daily treatment with Y-27632 (p.o., 100 mg/Kg). After 28 days from the MCT induction, rats were subjected to haemodynamic measurements. Right ventricle (RV) pressure was increased in MCT rats (61±7 vs 23±1 mm Hg). Y-27632 treatment attenuated this change (MCT+Y-27632: 33±2 mm Hg) without affecting systemic pressure (CTRL: 124±8; MCT 105±6; MCT+ Y-27632: 96±6 mm Hg). MCT-group developed RV hypertrophy which was not significantly counteracted by Y-27632. Morphometric analysis revealed that MCT increased distal pulmonary artery muscularization (alpha-SMA staining) compared to CTRL-group in pulmonary arteries sub-grouped according to diameter. Treatment with Y27632 significantly reduced the medial thickening of the arterioles, regardless the size (61-100 μm diameter: 23% reduction, 101-200 μm diameter: 16% reduction; 201-300 μm diameter: 15% reduction). Conclusions: In the rat MCT model, Y-27632 ameliorates hemodynamic parameters and pulmonary vascular remodelling, thus suggesting a therapeutic potential for pharmacological inhibition of ROCK." @default.
- W2550232145 created "2016-11-30" @default.
- W2550232145 creator A5003358525 @default.
- W2550232145 creator A5017348624 @default.
- W2550232145 creator A5020468911 @default.
- W2550232145 creator A5041007489 @default.
- W2550232145 creator A5063715630 @default.
- W2550232145 creator A5065992201 @default.
- W2550232145 creator A5080984469 @default.
- W2550232145 creator A5087386233 @default.
- W2550232145 date "2016-09-01" @default.
- W2550232145 modified "2023-09-23" @default.
- W2550232145 title "Hemodynamic and anti-remodelling effect of the Rho kinase inhibitor Y-27632 in the monocrotaline pulmonary arterial hypertension rat model" @default.
- W2550232145 doi "https://doi.org/10.1183/13993003.congress-2016.pa5100" @default.
- W2550232145 hasPublicationYear "2016" @default.
- W2550232145 type Work @default.
- W2550232145 sameAs 2550232145 @default.
- W2550232145 citedByCount "1" @default.
- W2550232145 countsByYear W25502321452022 @default.
- W2550232145 crossrefType "proceedings-article" @default.
- W2550232145 hasAuthorship W2550232145A5003358525 @default.
- W2550232145 hasAuthorship W2550232145A5017348624 @default.
- W2550232145 hasAuthorship W2550232145A5020468911 @default.
- W2550232145 hasAuthorship W2550232145A5041007489 @default.
- W2550232145 hasAuthorship W2550232145A5063715630 @default.
- W2550232145 hasAuthorship W2550232145A5065992201 @default.
- W2550232145 hasAuthorship W2550232145A5080984469 @default.
- W2550232145 hasAuthorship W2550232145A5087386233 @default.
- W2550232145 hasConcept C126322002 @default.
- W2550232145 hasConcept C149601957 @default.
- W2550232145 hasConcept C164705383 @default.
- W2550232145 hasConcept C167414201 @default.
- W2550232145 hasConcept C170493617 @default.
- W2550232145 hasConcept C178853913 @default.
- W2550232145 hasConcept C184235292 @default.
- W2550232145 hasConcept C185592680 @default.
- W2550232145 hasConcept C201800478 @default.
- W2550232145 hasConcept C2776048814 @default.
- W2550232145 hasConcept C2778609687 @default.
- W2550232145 hasConcept C2778921608 @default.
- W2550232145 hasConcept C2779376020 @default.
- W2550232145 hasConcept C2779961880 @default.
- W2550232145 hasConcept C2780930700 @default.
- W2550232145 hasConcept C2780940725 @default.
- W2550232145 hasConcept C55493867 @default.
- W2550232145 hasConcept C71924100 @default.
- W2550232145 hasConceptScore W2550232145C126322002 @default.
- W2550232145 hasConceptScore W2550232145C149601957 @default.
- W2550232145 hasConceptScore W2550232145C164705383 @default.
- W2550232145 hasConceptScore W2550232145C167414201 @default.
- W2550232145 hasConceptScore W2550232145C170493617 @default.
- W2550232145 hasConceptScore W2550232145C178853913 @default.
- W2550232145 hasConceptScore W2550232145C184235292 @default.
- W2550232145 hasConceptScore W2550232145C185592680 @default.
- W2550232145 hasConceptScore W2550232145C201800478 @default.
- W2550232145 hasConceptScore W2550232145C2776048814 @default.
- W2550232145 hasConceptScore W2550232145C2778609687 @default.
- W2550232145 hasConceptScore W2550232145C2778921608 @default.
- W2550232145 hasConceptScore W2550232145C2779376020 @default.
- W2550232145 hasConceptScore W2550232145C2779961880 @default.
- W2550232145 hasConceptScore W2550232145C2780930700 @default.
- W2550232145 hasConceptScore W2550232145C2780940725 @default.
- W2550232145 hasConceptScore W2550232145C55493867 @default.
- W2550232145 hasConceptScore W2550232145C71924100 @default.
- W2550232145 hasLocation W25502321451 @default.
- W2550232145 hasOpenAccess W2550232145 @default.
- W2550232145 hasPrimaryLocation W25502321451 @default.
- W2550232145 hasRelatedWork W1989649500 @default.
- W2550232145 hasRelatedWork W2041329079 @default.
- W2550232145 hasRelatedWork W2086771989 @default.
- W2550232145 hasRelatedWork W2151427027 @default.
- W2550232145 hasRelatedWork W2351626409 @default.
- W2550232145 hasRelatedWork W2362651156 @default.
- W2550232145 hasRelatedWork W2379335983 @default.
- W2550232145 hasRelatedWork W2393424567 @default.
- W2550232145 hasRelatedWork W2726671021 @default.
- W2550232145 hasRelatedWork W2885384177 @default.
- W2550232145 hasRelatedWork W2894628829 @default.
- W2550232145 hasRelatedWork W2992839672 @default.
- W2550232145 hasRelatedWork W3029662510 @default.
- W2550232145 hasRelatedWork W3031899590 @default.
- W2550232145 hasRelatedWork W3032300091 @default.
- W2550232145 hasRelatedWork W3095434340 @default.
- W2550232145 hasRelatedWork W3134286815 @default.
- W2550232145 hasRelatedWork W39080948 @default.
- W2550232145 hasRelatedWork W944599593 @default.
- W2550232145 hasRelatedWork W2304326389 @default.
- W2550232145 isParatext "false" @default.
- W2550232145 isRetracted "false" @default.
- W2550232145 magId "2550232145" @default.
- W2550232145 workType "article" @default.