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- W2550271010 abstract "Lung DiseaseThe innate immune response is poised to act quickly in the face of pathogenic invaders. However, this priming can incite a cytokine storm: excessive production of inflammatory cytokines that harm the host. Coon et al. now report that HECTD2, a ubiquitin E3 ligase, can degrade the anti-inflammatory protein PIAS1, enhancing this inflammatory effect. People with a polymorphism in the HECTD2 gene exhibit lower inflammation and are protected from acute respiratory distress syndrome. Moreover, a small-molecule inhibitor of HECTD2 reduced lung inflammation in mice. These observations pinpoint HECTD2 as a therapeutic target for inflammation-induced lung injury.Sci. Transl. Med. 7 , 295ra109 (2015)." @default.
- W2550271010 created "2016-11-30" @default.
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- W2550271010 date "2015-07-09" @default.
- W2550271010 modified "2023-09-25" @default.
- W2550271010 title "Calming the cytokine storm" @default.
- W2550271010 doi "https://doi.org/10.1126/science.349.6244.150-q" @default.
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