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- W2550274183 abstract "Background Mast cells (MCs) are immune cells present in the synovial membrane, and many evidences suggest that they contribute to the inflammatory response in Rheumatoid Arthritis (RA). However, their exact role in the pathogenesis of RA is still controversial. In particular, their presence in synovia and their association with the various histological patterns (pathothypes) described in RA have never been analysed systematically. Objectives To evaluate the presence of MCs in the synovial membrane of early RA patients and their correlation with synovial inflammation and cellular infiltration. Methods Sections of paraffin embedded synovial tissue obtained by ultrasound-guided synovial biopsy from DMARD-naive patients with early ( 2 ii) Myeloid- CD68 SL≥2, CD20≤1 and/or CD3≥1, CD138≤2 and iii) Fibroid- CD68 SL Results MCs were positively correlated with synovial inflammation (r S =0.657) and infiltrating T cells (r S =0.629), B cells (r S =0.666), macrophages (lining: r S =0.502; sub-lining r S =0.454) and plasma cells (r S =0.623), p 2 Vs fibroid/myeloid 11.66/mm 2 , p Conclusions Our study demonstrates that MCs strongly associate with the lymphoid synovial pathotype in early RA patients. Their ability to support B cell survival, activation and differentiation in vitro suggests that they may contribute to functional activation of lymphoid aggregates in vivo. Additional studies are warranted to establish the role of MC interaction with B cells and assess their usefulness as biomarker for patient stratification in RA. Acknowledgement The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union9s Seventh Framework Programme (FP7/2007–2013) under REA grant agreement n° 608765 Disclosure of Interest None declared" @default.
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- W2550274183 date "2016-06-01" @default.
- W2550274183 modified "2023-09-23" @default.
- W2550274183 title "FRI0043 Synovial Mast Cells Correlate with Local and Systemic Inflammation and Are Functionally Associated with Ectopic Lymphoid Structures in Patients with Early Rheumatoid Arthritis" @default.
- W2550274183 doi "https://doi.org/10.1136/annrheumdis-2016-eular.3163" @default.
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