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- W2550279460 abstract "Introduction: MicroRNAs (miRNAs) are critical regulators of most major cellular processes and seem to play a vital role in the pathogenesis of numerous diseases including atrial fibrillation, the most commonly encountered cardiac rhythm disorder. Among the several miRNAs that appear to be involved in pathogenesis of atrial fibrillation, miRNA 208a is linked to fibrosis and proper cardiac conduction. Methods and Results: By employing whole miRNA microarrays, 30 upregulated und 3 downregulated miRNAs were identified. The validation of the microarrays dataset in 19 left atrial appendage tissue samples (2 paroxysmal, 10 persistent, 7 long-standing persistent) was picked miRNA208, the most differentially expressed one. The relative expression level of miRNA 208a was 2.33 ± 1.99-fold of calibrator in atrial fibrillation tissue, whereas it was 1.4 E−4 ± 2.4 E−4 in RNA obtained from healthy donors control tissue, thus confirming the cardiac specific expression of this miRNA. Atrial fibrillation sub-categories revealed miRNA 208a expression levels of 2.32 ± 2.12 in paroxysmal, 3.26 ± 2.30 in persistent, and 1.14 ± 0.67 in long-standing persistent arrhythmias. The difference in miRNA 208a expression levels between persistent and long-standing persistent atrial fibrillation proved to be significant (p = 0.02). Discussion: The findings from our study suggest a decline in miRNA 208a expression with ongoing arrhythmia, possibly preceded by a rise in expression from paroxysmal to persistent atrial fibrillation or even long-standing persistent. The significant changes in miRNA 208a expression over the course of the disease may be used as an additional diagnostic tool to monitor the progression of atrial fibrillation." @default.
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- W2550279460 date "2015-01-20" @default.
- W2550279460 modified "2023-09-27" @default.
- W2550279460 title "MiRNA 208a Expression in Atrial Fibrillation Categories" @default.
- W2550279460 doi "https://doi.org/10.1055/s-0035-1544445" @default.
- W2550279460 hasPublicationYear "2015" @default.
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