FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2550285714> ?p ?o ?g. }

• W2550285714 endingPage "288" @default.
• W2550285714 startingPage "278" @default.
• W2550285714 abstract "Cytochrome P450s are a family of heme-containing enzymes that catalyze monooxygenation of inert substrates. Bacterial cytochrome P450s are great candidates as biocatalysts for synthetic applications because of their high hydroxylation activity and their high solubility in water. However, the substrate specificity of bacterial cytochrome P450s is generally high, and their low catalytic activities toward nonnative substrates tends to restrict their application as biocatalysts. We have developed a reaction system that utilizes dummy substrates with structures similar to those of natural substrates, as “decoy molecules”. The decoy molecules induce substrate misrecognition of bacterial P450s, leading to the generation of the active species and ultimately enabling them to catalyze the oxidation of nonnative substrates. The catalytic activity and the enantioselectivity are dependent on the structure of the decoy molecules, suggesting that the reactions can be controlled by variation in the designed structure of the decoy molecules. Cytochrome P450s are a family of heme-containing enzymes that catalyze monooxygenation of inert substrates. Bacterial cytochrome P450s are great candidates as biocatalysts for synthetic applications because of their high hydroxylation activity and their high solubility in water. However, the substrate specificity of bacterial cytochrome P450s is generally high, and their low catalytic activities toward nonnative substrates tends to restrict their applicable use as biocatalysts. We have developed a reaction system that utilize dummy substrates whose structures are similar to those of natural substrates, as “decoy molecules”. The decoy molecules induce substrate misrecognition of bacterial P450s, leading to the generation of the active species and ultimately enabling them to catalyze the oxidation of nonnative substrates. The catalytic activity and the enantioselectivity are dependent on the structure of the decoy molecules, suggesting that the reactions can be controlled by variation in the designed structure of the decoy molecules." @default.
• W2550285714 created "2016-11-30" @default.
• W2550285714 creator A5066307283 @default.
• W2550285714 creator A5073588774 @default.
• W2550285714 date "2017-03-05" @default.
• W2550285714 modified "2023-10-15" @default.
• W2550285714 title "Monooxygenation of Nonnative Substrates Catalyzed by Bacterial Cytochrome P450s Facilitated by Decoy Molecules" @default.
• W2550285714 cites W1485696779 @default.
• W2550285714 cites W1492818403 @default.
• W2550285714 cites W1963782724 @default.
• W2550285714 cites W1968400590 @default.
• W2550285714 cites W1971576421 @default.
• W2550285714 cites W1974181723 @default.
• W2550285714 cites W1975262546 @default.
• W2550285714 cites W1978480935 @default.
• W2550285714 cites W1979975835 @default.
• W2550285714 cites W1981824181 @default.
• W2550285714 cites W1982358683 @default.
• W2550285714 cites W1987856692 @default.
• W2550285714 cites W1990206990 @default.
• W2550285714 cites W1997377746 @default.
• W2550285714 cites W2000300598 @default.
• W2550285714 cites W2001057804 @default.
• W2550285714 cites W2002074698 @default.
• W2550285714 cites W2003929396 @default.
• W2550285714 cites W2007133890 @default.
• W2550285714 cites W2009056435 @default.
• W2550285714 cites W2009774095 @default.
• W2550285714 cites W2010933326 @default.
• W2550285714 cites W2012801837 @default.
• W2550285714 cites W2014406945 @default.
• W2550285714 cites W2015242558 @default.
• W2550285714 cites W2015978054 @default.
• W2550285714 cites W2017415116 @default.
• W2550285714 cites W2028191441 @default.
• W2550285714 cites W2051170144 @default.
• W2550285714 cites W2054783858 @default.
• W2550285714 cites W2057559300 @default.
• W2550285714 cites W2057718924 @default.
• W2550285714 cites W2058332165 @default.
• W2550285714 cites W2060766558 @default.
• W2550285714 cites W2063112093 @default.
• W2550285714 cites W2063121509 @default.
• W2550285714 cites W2070237585 @default.
• W2550285714 cites W2072676813 @default.
• W2550285714 cites W2077621515 @default.
• W2550285714 cites W2081526839 @default.
• W2550285714 cites W2089719184 @default.
• W2550285714 cites W2093491995 @default.
• W2550285714 cites W2095873332 @default.
• W2550285714 cites W2097930656 @default.
• W2550285714 cites W2104553116 @default.
• W2550285714 cites W2108738397 @default.
• W2550285714 cites W2109569743 @default.
• W2550285714 cites W2112593855 @default.
• W2550285714 cites W2118132519 @default.
• W2550285714 cites W2119679161 @default.
• W2550285714 cites W2122062071 @default.
• W2550285714 cites W2122919464 @default.
• W2550285714 cites W2124124969 @default.
• W2550285714 cites W2128703647 @default.
• W2550285714 cites W2140576468 @default.
• W2550285714 cites W2140615337 @default.
• W2550285714 cites W2146630606 @default.
• W2550285714 cites W2149796727 @default.
• W2550285714 cites W2150201595 @default.
• W2550285714 cites W2151246264 @default.
• W2550285714 cites W2152431497 @default.
• W2550285714 cites W2155037371 @default.
• W2550285714 cites W2155095892 @default.
• W2550285714 cites W2164873992 @default.
• W2550285714 cites W2165898505 @default.
• W2550285714 cites W2169817148 @default.
• W2550285714 cites W2322059647 @default.
• W2550285714 cites W2325323555 @default.
• W2550285714 cites W2333096653 @default.
• W2550285714 cites W2411889409 @default.
• W2550285714 cites W3213568968 @default.
• W2550285714 cites W4293258013 @default.
• W2550285714 doi "https://doi.org/10.1246/cl.160963" @default.
• W2550285714 hasPublicationYear "2017" @default.
• W2550285714 type Work @default.
• W2550285714 sameAs 2550285714 @default.
• W2550285714 citedByCount "24" @default.
• W2550285714 countsByYear W25502857142017 @default.
• W2550285714 countsByYear W25502857142018 @default.
• W2550285714 countsByYear W25502857142019 @default.
• W2550285714 countsByYear W25502857142020 @default.
• W2550285714 countsByYear W25502857142021 @default.
• W2550285714 countsByYear W25502857142022 @default.
• W2550285714 crossrefType "journal-article" @default.
• W2550285714 hasAuthorship W2550285714A5066307283 @default.
• W2550285714 hasAuthorship W2550285714A5073588774 @default.
• W2550285714 hasBestOaLocation W25502857141 @default.
• W2550285714 hasConcept C111368507 @default.
• W2550285714 hasConcept C127313418 @default.
• W2550285714 hasConcept C161790260 @default.
• W2550285714 hasConcept C178790620 @default.

• next