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- W2550331364 abstract "Background Inflammatory process in bone marrow (BM) observed on MRI scans of rheumatoid arthritis (RA) patients (called bone marrow oedema) together with autoantibodies production was shown to proceed joint destruction in RA. Our previous studies supported the concept that BM actively participate in the pathogenesis of RA by TLR triggered B cell activity (1) and increased number of activated T cells (2). Objectives In the present study we investigated IL-17 producers in BM. Methods BM and peripheral blood (PB) samples were obtained from RA and osteoarthritis (OA) patients during total hip replacement surgery. Levels of IL-17AF, IL-17FF, IL-17AA, GMCSF and IL-21 in bone marrow plasma were determined by specific ELISA. Th1/Th2/Th17 proportions were evaluated by flow cytometry. To confirm production of IL-17 in BM immunohistochemistry examination was done. Comparison between the groups of patients were analysed by two-tailed Mann-Whitney U test. Results We observed increased level of IL-17AF (147±104 pg/ml vs 115±74pg/ml, p Conclusions IL-17AF is overproduced in RA bone marrow. There are two main sources of these cytokine in RA BM: T cells and granulocytes References W Rudnicka et al.: Eur J Immunol 2009; 1211–20 E Kuca-warnawin et al.: Ann Rheum Dis 2011;227–33 Acknowledgement This work was sponsored by by grant No UMO-2011/03/B/NZ6/05035 from National Science Centre Disclosure of Interest None declared" @default.
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- W2550331364 date "2016-06-01" @default.
- W2550331364 modified "2023-09-27" @default.
- W2550331364 title "FRI0012 IL-17 in Rheumatoid Arthritis Bone Marrow. Not Only Th-17 Cells" @default.
- W2550331364 doi "https://doi.org/10.1136/annrheumdis-2016-eular.4378" @default.
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