Matches in SemOpenAlex for { <https://semopenalex.org/work/W2550335841> ?p ?o ?g. }
- W2550335841 endingPage "81740" @default.
- W2550335841 startingPage "81727" @default.
- W2550335841 abstract "APC (80-90%) and K-Ras (40-50%) mutations frequently occur in human colorectal cancer (CRC) and these mutations cooperatively accelerate tumorigenesis including metastasis. In addition, both β-catenin and Ras levels are highly increased in CRC, especially in metastatic CRC (mCRC). Therefore, targeting both the Wnt/β-catenin and Ras pathways could be an ideal therapeutic approach for treating mCRC patients. In this study, we characterized the roles of KY1022, a small molecule that destabilizes both β-catenin and Ras via targeting the Wnt/β-catenin pathway, in inhibiting the cellular events, including EMT, an initial process of metastasis, and apoptosis. As shown by in vitro and in vivo studies using APCMin/+/K-RasG12DLA2 mice, KY1022 effectively suppressed the development of mCRC at an early stage of tumorigenesis. A small molecular approach degrading both β-catenin and Ras via inhibition of the Wnt/β-catenin signaling would be an ideal strategy for treatment of mCRC." @default.
- W2550335841 created "2016-11-30" @default.
- W2550335841 creator A5000975757 @default.
- W2550335841 creator A5010211109 @default.
- W2550335841 creator A5013075854 @default.
- W2550335841 creator A5037735584 @default.
- W2550335841 creator A5055083737 @default.
- W2550335841 creator A5060939605 @default.
- W2550335841 creator A5064637828 @default.
- W2550335841 creator A5067662275 @default.
- W2550335841 creator A5067941687 @default.
- W2550335841 creator A5070506137 @default.
- W2550335841 creator A5076141721 @default.
- W2550335841 creator A5086381106 @default.
- W2550335841 creator A5090926704 @default.
- W2550335841 date "2016-11-07" @default.
- W2550335841 modified "2023-10-14" @default.
- W2550335841 title "KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer" @default.
- W2550335841 cites W1545207724 @default.
- W2550335841 cites W1603215427 @default.
- W2550335841 cites W1823067696 @default.
- W2550335841 cites W1965157206 @default.
- W2550335841 cites W1970766774 @default.
- W2550335841 cites W1992372073 @default.
- W2550335841 cites W2001258296 @default.
- W2550335841 cites W2006648625 @default.
- W2550335841 cites W2012565727 @default.
- W2550335841 cites W2014260136 @default.
- W2550335841 cites W2018425992 @default.
- W2550335841 cites W2018757657 @default.
- W2550335841 cites W2026262319 @default.
- W2550335841 cites W2038624343 @default.
- W2550335841 cites W2044409144 @default.
- W2550335841 cites W2045822703 @default.
- W2550335841 cites W2049186397 @default.
- W2550335841 cites W2062109911 @default.
- W2550335841 cites W2063099096 @default.
- W2550335841 cites W2064644124 @default.
- W2550335841 cites W2070421660 @default.
- W2550335841 cites W2071841826 @default.
- W2550335841 cites W2086627696 @default.
- W2550335841 cites W2091935713 @default.
- W2550335841 cites W2093531978 @default.
- W2550335841 cites W2093947855 @default.
- W2550335841 cites W2099353036 @default.
- W2550335841 cites W2108360007 @default.
- W2550335841 cites W2118474093 @default.
- W2550335841 cites W2124715710 @default.
- W2550335841 cites W2135500767 @default.
- W2550335841 cites W2149402504 @default.
- W2550335841 cites W2151457918 @default.
- W2550335841 cites W2153128764 @default.
- W2550335841 cites W2160120862 @default.
- W2550335841 cites W2169580709 @default.
- W2550335841 cites W2226889062 @default.
- W2550335841 cites W2235523093 @default.
- W2550335841 cites W2418633760 @default.
- W2550335841 cites W2421886702 @default.
- W2550335841 doi "https://doi.org/10.18632/oncotarget.13172" @default.
- W2550335841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5348425" @default.
- W2550335841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27835580" @default.
- W2550335841 hasPublicationYear "2016" @default.
- W2550335841 type Work @default.
- W2550335841 sameAs 2550335841 @default.
- W2550335841 citedByCount "28" @default.
- W2550335841 countsByYear W25503358412017 @default.
- W2550335841 countsByYear W25503358412018 @default.
- W2550335841 countsByYear W25503358412019 @default.
- W2550335841 countsByYear W25503358412020 @default.
- W2550335841 countsByYear W25503358412021 @default.
- W2550335841 countsByYear W25503358412022 @default.
- W2550335841 countsByYear W25503358412023 @default.
- W2550335841 crossrefType "journal-article" @default.
- W2550335841 hasAuthorship W2550335841A5000975757 @default.
- W2550335841 hasAuthorship W2550335841A5010211109 @default.
- W2550335841 hasAuthorship W2550335841A5013075854 @default.
- W2550335841 hasAuthorship W2550335841A5037735584 @default.
- W2550335841 hasAuthorship W2550335841A5055083737 @default.
- W2550335841 hasAuthorship W2550335841A5060939605 @default.
- W2550335841 hasAuthorship W2550335841A5064637828 @default.
- W2550335841 hasAuthorship W2550335841A5067662275 @default.
- W2550335841 hasAuthorship W2550335841A5067941687 @default.
- W2550335841 hasAuthorship W2550335841A5070506137 @default.
- W2550335841 hasAuthorship W2550335841A5076141721 @default.
- W2550335841 hasAuthorship W2550335841A5086381106 @default.
- W2550335841 hasAuthorship W2550335841A5090926704 @default.
- W2550335841 hasBestOaLocation W25503358411 @default.
- W2550335841 hasConcept C111669997 @default.
- W2550335841 hasConcept C121608353 @default.
- W2550335841 hasConcept C126322002 @default.
- W2550335841 hasConcept C137620995 @default.
- W2550335841 hasConcept C207001950 @default.
- W2550335841 hasConcept C2779013556 @default.
- W2550335841 hasConcept C2779324961 @default.
- W2550335841 hasConcept C30145163 @default.
- W2550335841 hasConcept C502942594 @default.
- W2550335841 hasConcept C526805850 @default.
- W2550335841 hasConcept C54355233 @default.