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- W2550360912 abstract "Calcium phosphate cements (CPC) have seen clinical success in many dental and orthopaedic applications in recent years. The properties of CPC essential for clinical success are reviewed in this article, which includes properties of the set cement (e.g. bioresorbability, biocompatibility, porosity and mechanical properties) and unset cement (e.g. setting time, cohesion, flow properties and ease of delivery to the surgical site). Emphasis is on the delivery of calcium phosphate (CaP) pastes and CPC, in particular the occurrence of separation of the liquid and solid components of the pastes and cements during injection; and established methods to reduce this phase separation. In addition a review of phase separation mechanisms observed during the extrusion of other biphasic paste systems and the theoretical models used to describe these mechanisms are discussed.Occurrence of phase separation of calcium phosphate pastes and cements during injection limits their full exploitation as a bone substitute in minimally invasive surgical applications. Due to lack of theoretical understanding of the phase separation mechanism(s), optimisation of an injectable CPC that satisfies clinical requirements has proven difficult. However, phase separation of pastes during delivery has been the focus across several research fields. Therefore in addition to a review of methods to reduce phase separation of CPC and the associated constraints, a review of phase separation mechanisms observed during extrusion of other pastes and the theoretical models used to describe these mechanisms is presented. It is anticipated this review will benefit future attempts to develop injectable calcium phosphate based systems." @default.
- W2550360912 created "2016-11-30" @default.
- W2550360912 creator A5014770050 @default.
- W2550360912 creator A5027763356 @default.
- W2550360912 creator A5030513834 @default.
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- W2550360912 creator A5081151755 @default.
- W2550360912 creator A5083229558 @default.
- W2550360912 creator A5089566984 @default.
- W2550360912 date "2017-03-01" @default.
- W2550360912 modified "2023-10-18" @default.
- W2550360912 title "Critical review: Injectability of calcium phosphate pastes and cements" @default.
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