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- W2550374742 abstract "1.Thyroid hormone is essential for the development of various tissues, especially in the developing brain.2.Several classes of transporters, such as organic anion transporting polypeptides (OATP1C1/Oatp1c1), monocarboxylate transporters (Mct8/MCT8), and amino acid transporters (Lat1/LAT1), are expressed in different components of the central nervous system (i.e., blood brain barrier, astrocytes, and neurons), functioning concertedly (see Fig. 11.1).3.The fact that only MCT8 and Oatp1c1 double knockout mice displayed more severely decreased uptakes and contents of T3 and T4 in brain as well as exhibited more impaired brain development phenotypes (delayed cerebellar development, reduced myelination, and abnormal locomotor activities), suggesting compensations and redundancies of thyroid hormone transportation in the brain by several different transporters." @default.
- W2550374742 created "2016-11-30" @default.
- W2550374742 creator A5061369169 @default.
- W2550374742 creator A5072067649 @default.
- W2550374742 date "2016-01-01" @default.
- W2550374742 modified "2023-10-16" @default.
- W2550374742 title "Deficit in Thyroid Hormone Transporters and Brain Development" @default.
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- W2550374742 doi "https://doi.org/10.1007/978-1-4939-3737-0_11" @default.
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