FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2550488380> ?p ?o ?g. }

• W2550488380 endingPage "e0165689" @default.
• W2550488380 startingPage "e0165689" @default.
• W2550488380 abstract "Regular resistance exercise induces skeletal muscle hypertrophy and improvement of glycemic control in type 2 diabetes patients. Administration of dehydroepiandrosterone (DHEA), a sex steroid hormone precursor, increases 5α-dihydrotestosterone (DHT) synthesis and is associated with improvements in fasting blood glucose level and skeletal muscle hypertrophy. Therefore, the aim of this study was to investigate whether increase in muscle DHT levels, induced by chronic resistance exercise, can contribute to skeletal muscle hypertrophy and concomitant improvement of muscular glucose metabolism in type 2 diabetic rats. Male 20-week-old type 2 diabetic rats (OLETF) were randomly divided into 3 groups: sedentary control, resistance training (3 times a week on alternate days for 8 weeks), or resistance training with continuous infusion of a 5α-reductase inhibitor (n = 8 each group). Age-matched, healthy nondiabetic Long-Evans Tokushima Otsuka (LETO) rats (n = 8) were used as controls. The results indicated that OLETF rats showed significant decrease in muscular DHEA, free testosterone, DHT levels, and protein expression of steroidogenic enzymes, with loss of skeletal muscle mass and hyperglycemia, compared to that of LETO rats. However, 8-week resistance training in OLETF rats significantly increased the levels of muscle sex steroid hormones and protein expression of steroidogenic enzymes with a concomitant increase in skeletal muscle mass, improved fasting glucose level, and insulin sensitivity index. Moreover, resistance training accelerated glucose transporter-4 (GLUT-4) translocation and protein kinase B and C-ζ/λ phosphorylation. Administering the 5α-reductase inhibitor in resistance-trained OLETF rats resulted in suppression of the exercise-induced effects on skeletal muscle mass, fasting glucose level, insulin sensitivity index, and GLUT-4 signaling, with a decline in muscular DHT levels. These findings suggest that resistance training-induced elevation of muscular DHT levels may contribute to improvement of hyperglycemia and skeletal muscle hypertrophy in type 2 diabetic rats." @default.
• W2550488380 created "2016-11-30" @default.
• W2550488380 creator A5007346393 @default.
• W2550488380 creator A5033340710 @default.
• W2550488380 creator A5064689365 @default.
• W2550488380 creator A5069842782 @default.
• W2550488380 date "2016-11-10" @default.
• W2550488380 modified "2023-09-27" @default.
• W2550488380 title "Increased Muscular 5α-Dihydrotestosterone in Response to Resistance Training Relates to Skeletal Muscle Mass and Glucose Metabolism in Type 2 Diabetic Rats" @default.
• W2550488380 cites W1898907048 @default.
• W2550488380 cites W1977023983 @default.
• W2550488380 cites W1984304425 @default.
• W2550488380 cites W2003166113 @default.
• W2550488380 cites W2006268551 @default.
• W2550488380 cites W2027764283 @default.
• W2550488380 cites W2054950088 @default.
• W2550488380 cites W2068254028 @default.
• W2550488380 cites W2091045082 @default.
• W2550488380 cites W2100378647 @default.
• W2550488380 cites W2103672262 @default.
• W2550488380 cites W2104063796 @default.
• W2550488380 cites W2106559777 @default.
• W2550488380 cites W2108904664 @default.
• W2550488380 cites W2109259286 @default.
• W2550488380 cites W2124956707 @default.
• W2550488380 cites W2131325881 @default.
• W2550488380 cites W2136743230 @default.
• W2550488380 cites W2149226861 @default.
• W2550488380 cites W2150803463 @default.
• W2550488380 cites W2153401503 @default.
• W2550488380 cites W2155553060 @default.
• W2550488380 cites W2161364942 @default.
• W2550488380 cites W2165474199 @default.
• W2550488380 cites W2169312890 @default.
• W2550488380 cites W2186906724 @default.
• W2550488380 cites W2256284544 @default.
• W2550488380 cites W2261441533 @default.
• W2550488380 cites W2277470901 @default.
• W2550488380 doi "https://doi.org/10.1371/journal.pone.0165689" @default.
• W2550488380 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5104401" @default.
• W2550488380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27832095" @default.
• W2550488380 hasPublicationYear "2016" @default.
• W2550488380 type Work @default.
• W2550488380 sameAs 2550488380 @default.
• W2550488380 citedByCount "14" @default.
• W2550488380 countsByYear W25504883802017 @default.
• W2550488380 countsByYear W25504883802018 @default.
• W2550488380 countsByYear W25504883802019 @default.
• W2550488380 countsByYear W25504883802020 @default.
• W2550488380 countsByYear W25504883802021 @default.
• W2550488380 countsByYear W25504883802022 @default.
• W2550488380 countsByYear W25504883802023 @default.
• W2550488380 crossrefType "journal-article" @default.
• W2550488380 hasAuthorship W2550488380A5007346393 @default.
• W2550488380 hasAuthorship W2550488380A5033340710 @default.
• W2550488380 hasAuthorship W2550488380A5064689365 @default.
• W2550488380 hasAuthorship W2550488380A5069842782 @default.
• W2550488380 hasBestOaLocation W25504883801 @default.
• W2550488380 hasConcept C126322002 @default.
• W2550488380 hasConcept C134018914 @default.
• W2550488380 hasConcept C167414201 @default.
• W2550488380 hasConcept C2777180221 @default.
• W2550488380 hasConcept C2777391703 @default.
• W2550488380 hasConcept C2777911890 @default.
• W2550488380 hasConcept C2779279991 @default.
• W2550488380 hasConcept C2779881493 @default.
• W2550488380 hasConcept C2779959927 @default.
• W2550488380 hasConcept C555293320 @default.
• W2550488380 hasConcept C71315377 @default.
• W2550488380 hasConcept C71924100 @default.
• W2550488380 hasConceptScore W2550488380C126322002 @default.
• W2550488380 hasConceptScore W2550488380C134018914 @default.
• W2550488380 hasConceptScore W2550488380C167414201 @default.
• W2550488380 hasConceptScore W2550488380C2777180221 @default.
• W2550488380 hasConceptScore W2550488380C2777391703 @default.
• W2550488380 hasConceptScore W2550488380C2777911890 @default.
• W2550488380 hasConceptScore W2550488380C2779279991 @default.
• W2550488380 hasConceptScore W2550488380C2779881493 @default.
• W2550488380 hasConceptScore W2550488380C2779959927 @default.
• W2550488380 hasConceptScore W2550488380C555293320 @default.
• W2550488380 hasConceptScore W2550488380C71315377 @default.
• W2550488380 hasConceptScore W2550488380C71924100 @default.
• W2550488380 hasFunder F4320334764 @default.
• W2550488380 hasIssue "11" @default.
• W2550488380 hasLocation W25504883801 @default.
• W2550488380 hasLocation W25504883802 @default.
• W2550488380 hasLocation W25504883803 @default.
• W2550488380 hasLocation W25504883804 @default.
• W2550488380 hasLocation W25504883805 @default.
• W2550488380 hasOpenAccess W2550488380 @default.
• W2550488380 hasPrimaryLocation W25504883801 @default.
• W2550488380 hasRelatedWork W1981433740 @default.
• W2550488380 hasRelatedWork W2002995968 @default.
• W2550488380 hasRelatedWork W2026882188 @default.
• W2550488380 hasRelatedWork W2027210979 @default.
• W2550488380 hasRelatedWork W2038277505 @default.
• W2550488380 hasRelatedWork W2040570848 @default.
• W2550488380 hasRelatedWork W2052998204 @default.

• next