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- W2550546953 endingPage "160246" @default.
- W2550546953 startingPage "160246" @default.
- W2550546953 abstract "Translational readthrough gives rise to C-terminally extended proteins, thereby providing the cell with new protein isoforms. These may have different properties from the parental proteins if the extensions contain functional domains. While for most genes amino acid incorporation at the stop codon is far lower than 0.1%, about 4% of malate dehydrogenase (MDH1) is physiologically extended by translational readthrough and the actual ratio of MDH1x (extended protein) to 'normal' MDH1 is dependent on the cell type. In human cells, arginine and tryptophan are co-encoded by the MDH1x UGA stop codon. Readthrough is controlled by the 7-nucleotide high-readthrough stop codon context without contribution of the subsequent 50 nucleotides encoding the extension. All vertebrate MDH1x is directed to peroxisomes via a hidden peroxisomal targeting signal (PTS) in the readthrough extension, which is more highly conserved than the extension of lactate dehydrogenase B. The hidden PTS of non-mammalian MDH1x evolved to be more efficient than the PTS of mammalian MDH1x. These results provide insight into the genetic and functional co-evolution of these dually localized dehydrogenases." @default.
- W2550546953 created "2016-11-30" @default.
- W2550546953 creator A5018036449 @default.
- W2550546953 creator A5020966886 @default.
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- W2550546953 creator A5053722819 @default.
- W2550546953 creator A5064614134 @default.
- W2550546953 creator A5076561076 @default.
- W2550546953 creator A5079537507 @default.
- W2550546953 date "2016-11-01" @default.
- W2550546953 modified "2023-10-12" @default.
- W2550546953 title "The functional readthrough extension of malate dehydrogenase reveals a modification of the genetic code" @default.
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- W2550546953 doi "https://doi.org/10.1098/rsob.160246" @default.
- W2550546953 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5133446" @default.
- W2550546953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27881739" @default.
- W2550546953 hasPublicationYear "2016" @default.
- W2550546953 type Work @default.