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- W2550586415 abstract "Introduction As per GOLD strategy, ICS combined with a LABA and/or a LAMA is a first line choice to treat COPD patients (pts) at a high risk of exacerbations. However, there is widespread use of ICS in COPD pts who do not meet the GOLD criteria for its use. ICS use has been associated with systemic side effects such as suppression of hypothalamic pituitary-adrenal (HPA) axis function (decreased production of endogenous glucocorticosteriods). This reflects the systemic burden of ICS which can be associated with long-term consequences. Here, we present results for indacaterol/glycopyrronium (IND/GLY; LABA/LAMA) vs. salmeterol/fluticasone (SFC; LABA/ICS) in terms of HPA-axis function from the FLAME study. Methods FLAME was a 52-week, multicentre, double-blind study that randomised (1:1) moderate-to-very severe COPD pts (postbronchodilator FEV 1 ≥25 and Results Of 3362 randomised pts, 535 were included in the urine cortisol set. Median urine cortisol level decreased by 8.67% with SFC treatment, while the level increased by 1.42% with IND/GLY treatment from baseline at Week 52. Consistently, median cortisol/creatinine ratio reduced with SFC (by 10.39%) and increased with IND/GLY (by 5.62%) from baseline following 52-week treatment. Conclusion SFC but not IND/GLY treatment was associated with suppression of HPA-axis function in moderate-to-very severe COPD patients, confirming systemic effects of SFC." @default.
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- W2550586415 date "2016-09-01" @default.
- W2550586415 modified "2023-09-23" @default.
- W2550586415 title "Effect of indacaterol/glycopyrronium versus salmeterol/fluticasone on hypothalamic pituitary-adrenal axis function in moderate-to-very severe COPD patients: Results from the FLAME study" @default.
- W2550586415 doi "https://doi.org/10.1183/13993003.congress-2016.pa984" @default.
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