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• W2550641796 abstract "<b><i>Background:</i></b> Depression-related gray matter changes in Parkinson disease (PD) patients have been reported, although studies investigating cortical thickness in early-stage disease are lacking. <b><i>Objective:</i></b> We aimed to evaluate cortical changes related to depression in early-stage PD patients with an extensive neuropsychological evaluation. <b><i>Methods:</i></b> 17 PD patients and 22 healthy controls underwent a 1.5-T brain MR protocol, and voxel-wise differences in cortical thickness among patients with (<i>n</i> = 6) and without (<i>n</i> = 11) depression and controls were evaluated using FreeSurfer software. <b><i>Results:</i></b> Cortical thickness was increased in the precuneus bilaterally in PD patients with depression compared to the other groups (number of vertices >100; <i>p</i> < 0.001, uncorrected) with a direct correlation with the Beck Depression Inventory score (<i>p</i> < 0.001, uncorrected). <b><i>Conclusion:</i></b> Precuneal cortical thickening is evident in PD patients with mild-moderate depression even in the early stages of the disease. This finding may reflect the early involvement of this region in the development of PD-related depression." @default.
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• W2550641796 date "2016-11-24" @default.
• W2550641796 modified "2023-10-18" @default.
• W2550641796 title "Precuneal Thickness and Depression in Parkinson Disease" @default.
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• W2550641796 doi "https://doi.org/10.1159/000450614" @default.
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