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- W2550661840 abstract "Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling that leads to pulmonary congestion, uncompensated right-ventricle (RV) failure, and premature death. Preclinical studies have demonstrated that the G protein-coupled estrogen receptor (GPER) is cardioprotective in male rats and that its activation elicits vascular relaxation in rats of either sex.To study the effects of GPER on the cardiopulmonary system by the administration of its selective agonist G1 in male rats with monocrotaline (MCT)-induced PH.Rats received a single intraperitoneal injection of MCT (60mg/kg) for PH induction. Experimental groups were as follows: control, MCT+vehicle, and MCT+G1 (400μg/kg/daysubcutaneous). Animals (n=5pergroup) were treated with vehicle or G1 for 14days after disease onset.Activation of GPER attenuated exercise intolerance and reduced RV overload in PH rats. Rats with PH exhibited echocardiographic alterations, such as reduced pulmonary flow, RV hypertrophy, and left-ventricle dysfunction, by the end of protocol. G1 treatment reversed these PH-related abnormalities of cardiopulmonary function and structure, in part by promoting pulmonary endothelial nitric oxide synthesis, Ca2+ handling regulation and reduction of inflammation in cardiomyocytes, and a decrease of collagen deposition by acting in pulmonary and cardiac fibroblasts.G1 was effective to reverse PH-induced RV dysfunction and exercise intolerance in male rats, a finding that have important implications for ongoing clinical evaluation of new cardioprotective and vasodilator drugs for the treatment of the disease." @default.
- W2550661840 created "2016-11-30" @default.
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- W2550661840 date "2017-01-01" @default.
- W2550661840 modified "2023-10-08" @default.
- W2550661840 title "Activation of GPER ameliorates experimental pulmonary hypertension in male rats" @default.
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- W2550661840 cites W1944407813 @default.
- W2550661840 cites W1972086601 @default.
- W2550661840 cites W1973349963 @default.
- W2550661840 cites W1976530143 @default.
- W2550661840 cites W1977113205 @default.
- W2550661840 cites W1977966424 @default.
- W2550661840 cites W1979639957 @default.
- W2550661840 cites W1980166578 @default.
- W2550661840 cites W1983349129 @default.
- W2550661840 cites W1987685975 @default.
- W2550661840 cites W1987928893 @default.
- W2550661840 cites W1999894142 @default.
- W2550661840 cites W2002493975 @default.
- W2550661840 cites W2005469488 @default.
- W2550661840 cites W2011477996 @default.
- W2550661840 cites W2013766385 @default.
- W2550661840 cites W2018064469 @default.
- W2550661840 cites W2024297443 @default.
- W2550661840 cites W2035041945 @default.
- W2550661840 cites W2035077482 @default.
- W2550661840 cites W2037790468 @default.
- W2550661840 cites W2038311789 @default.
- W2550661840 cites W2038525812 @default.
- W2550661840 cites W2039698855 @default.
- W2550661840 cites W2040179836 @default.
- W2550661840 cites W2046002743 @default.
- W2550661840 cites W2047136594 @default.
- W2550661840 cites W2049116118 @default.
- W2550661840 cites W2061966564 @default.
- W2550661840 cites W2063608650 @default.
- W2550661840 cites W2067470036 @default.
- W2550661840 cites W2067887158 @default.
- W2550661840 cites W2069288112 @default.
- W2550661840 cites W2069561389 @default.
- W2550661840 cites W2070023795 @default.
- W2550661840 cites W2077651427 @default.
- W2550661840 cites W2084667752 @default.
- W2550661840 cites W2092398617 @default.
- W2550661840 cites W2097076005 @default.
- W2550661840 cites W2101249203 @default.
- W2550661840 cites W2114913702 @default.
- W2550661840 cites W2122637827 @default.
- W2550661840 cites W2125263078 @default.
- W2550661840 cites W2130425604 @default.
- W2550661840 cites W2135628956 @default.
- W2550661840 cites W2136094484 @default.
- W2550661840 cites W2138650758 @default.
- W2550661840 cites W2140002693 @default.
- W2550661840 cites W2140058582 @default.
- W2550661840 cites W2146578470 @default.
- W2550661840 cites W2147381969 @default.
- W2550661840 cites W2148557611 @default.
- W2550661840 cites W2148764267 @default.
- W2550661840 cites W2149713530 @default.
- W2550661840 cites W2158749167 @default.
- W2550661840 cites W2164016109 @default.
- W2550661840 cites W2166302693 @default.
- W2550661840 cites W2170331970 @default.
- W2550661840 cites W2269850420 @default.
- W2550661840 cites W2307104826 @default.
- W2550661840 cites W2324476825 @default.
- W2550661840 cites W2345318086 @default.
- W2550661840 cites W2768781271 @default.
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- W2550661840 doi "https://doi.org/10.1016/j.ejps.2016.11.009" @default.
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- W2550661840 hasPublicationYear "2017" @default.
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