FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2550665232> ?p ?o ?g. }

• W2550665232 endingPage "69" @default.
• W2550665232 startingPage "63" @default.
• W2550665232 abstract "IntroductionThe goal of this study was too test the efficacy of carvedilol (CAR), an adrenergic blocker, for reducing cocaine use in individuals with cocaine use disorder (CUD). We conducted a 17-week, double-blind, randomized controlled trial with 3 treatment arms: 25 mg CAR, 50 mg CAR, and placebo.MethodsOne hundred and six treatment-seeking opioid and cocaine-dependent participants, who were also maintained on methadone during study participation, were randomized to placebo (n = 34), 25 mg/day CAR (n = 37) or 50 mg/day CAR (n = 35). The main outcome measures were cocaine and opioid use as assessed by urine drug screening and self-reported drug use.ResultsNo significant group differences were found for treatment retention with 56% of the placebo, 76% of the 25 mg and 66% of the 50 mg CAR groups (p > 0.05) completing treatment. The percentage (SD) of cocaine positive urines during the trial showed an overall treatment effect: 59.2 (38.9) for the placebo, 50.8 (33.8) for the 25 mg and 75.1 (33.2) for the 50 mg CAR group. In post hoc comparisons, neither the 25 nor 50 mg CAR condition differed significantly from the placebo; however, the 25 mg CAR group had a significantly lower proportion of cocaine-positive urines than the 50 mg group. No significant group differences were found for the percentage of self-reported days of cocaine abstinence during the trial: 72.9 (25.3) for placebo, 72.9 (29) for CAR 25 mg, and 59.3 (31.7) for CAR 50 mg. Significant groups differences in the proportion of opioid positive urines submitted were not observed (p > 0.05). Baseline cocaine withdrawal severity did not predict treatment response (p > 0.05).ConclusionsThese findings did not support the efficacy of CAR for the treatment of cocaine use in cocaine and opioid dependent participants maintained on methadone. Further, CAR doses >25 mg should not be used to avoid possible increases in cocaine and opioid use." @default.
• W2550665232 created "2016-11-30" @default.
• W2550665232 creator A5003422790 @default.
• W2550665232 creator A5032244956 @default.
• W2550665232 creator A5042681925 @default.
• W2550665232 creator A5044842506 @default.
• W2550665232 creator A5052654379 @default.
• W2550665232 creator A5084852641 @default.
• W2550665232 creator A5087683644 @default.
• W2550665232 date "2017-02-01" @default.
• W2550665232 modified "2023-10-18" @default.
• W2550665232 title "Carvedilol does not reduce cocaine use in methadone-maintained cocaine users" @default.
• W2550665232 cites W1578324244 @default.
• W2550665232 cites W1979518499 @default.
• W2550665232 cites W1984299054 @default.
• W2550665232 cites W1990473903 @default.
• W2550665232 cites W1995638617 @default.
• W2550665232 cites W2009527701 @default.
• W2550665232 cites W2009558291 @default.
• W2550665232 cites W2035086406 @default.
• W2550665232 cites W2047771595 @default.
• W2550665232 cites W2067020991 @default.
• W2550665232 cites W2067812968 @default.
• W2550665232 cites W2069617165 @default.
• W2550665232 cites W2073773595 @default.
• W2550665232 cites W2078862169 @default.
• W2550665232 cites W2080083219 @default.
• W2550665232 cites W2083490393 @default.
• W2550665232 cites W2088645714 @default.
• W2550665232 cites W2089550064 @default.
• W2550665232 cites W2108304662 @default.
• W2550665232 cites W2109406833 @default.
• W2550665232 cites W2112778345 @default.
• W2550665232 cites W2114613490 @default.
• W2550665232 cites W2114843987 @default.
• W2550665232 cites W2114864255 @default.
• W2550665232 cites W2115610172 @default.
• W2550665232 cites W2143813059 @default.
• W2550665232 cites W2154809561 @default.
• W2550665232 cites W4205320581 @default.
• W2550665232 cites W4235655641 @default.
• W2550665232 doi "https://doi.org/10.1016/j.jsat.2016.11.005" @default.
• W2550665232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5193370" @default.
• W2550665232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28017186" @default.
• W2550665232 hasPublicationYear "2017" @default.
• W2550665232 type Work @default.
• W2550665232 sameAs 2550665232 @default.
• W2550665232 citedByCount "5" @default.
• W2550665232 countsByYear W25506652322019 @default.
• W2550665232 countsByYear W25506652322020 @default.
• W2550665232 countsByYear W25506652322021 @default.
• W2550665232 countsByYear W25506652322022 @default.
• W2550665232 crossrefType "journal-article" @default.
• W2550665232 hasAuthorship W2550665232A5003422790 @default.
• W2550665232 hasAuthorship W2550665232A5032244956 @default.
• W2550665232 hasAuthorship W2550665232A5042681925 @default.
• W2550665232 hasAuthorship W2550665232A5044842506 @default.
• W2550665232 hasAuthorship W2550665232A5052654379 @default.
• W2550665232 hasAuthorship W2550665232A5084852641 @default.
• W2550665232 hasAuthorship W2550665232A5087683644 @default.
• W2550665232 hasBestOaLocation W25506652322 @default.
• W2550665232 hasConcept C118552586 @default.
• W2550665232 hasConcept C126322002 @default.
• W2550665232 hasConcept C142724271 @default.
• W2550665232 hasConcept C15744967 @default.
• W2550665232 hasConcept C168563851 @default.
• W2550665232 hasConcept C170493617 @default.
• W2550665232 hasConcept C204787440 @default.
• W2550665232 hasConcept C27081682 @default.
• W2550665232 hasConcept C2778767360 @default.
• W2550665232 hasConcept C2778903061 @default.
• W2550665232 hasConcept C2779796075 @default.
• W2550665232 hasConcept C2780687700 @default.
• W2550665232 hasConcept C2781063702 @default.
• W2550665232 hasConcept C42219234 @default.
• W2550665232 hasConcept C48856860 @default.
• W2550665232 hasConcept C71924100 @default.
• W2550665232 hasConceptScore W2550665232C118552586 @default.
• W2550665232 hasConceptScore W2550665232C126322002 @default.
• W2550665232 hasConceptScore W2550665232C142724271 @default.
• W2550665232 hasConceptScore W2550665232C15744967 @default.
• W2550665232 hasConceptScore W2550665232C168563851 @default.
• W2550665232 hasConceptScore W2550665232C170493617 @default.
• W2550665232 hasConceptScore W2550665232C204787440 @default.
• W2550665232 hasConceptScore W2550665232C27081682 @default.
• W2550665232 hasConceptScore W2550665232C2778767360 @default.
• W2550665232 hasConceptScore W2550665232C2778903061 @default.
• W2550665232 hasConceptScore W2550665232C2779796075 @default.
• W2550665232 hasConceptScore W2550665232C2780687700 @default.
• W2550665232 hasConceptScore W2550665232C2781063702 @default.
• W2550665232 hasConceptScore W2550665232C42219234 @default.
• W2550665232 hasConceptScore W2550665232C48856860 @default.
• W2550665232 hasConceptScore W2550665232C71924100 @default.
• W2550665232 hasLocation W25506652321 @default.
• W2550665232 hasLocation W25506652322 @default.
• W2550665232 hasLocation W25506652323 @default.
• W2550665232 hasLocation W25506652324 @default.
• W2550665232 hasOpenAccess W2550665232 @default.

• next