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• W2550671199 abstract "Determine the incidence of resting state oscillations in alpha/beta, high frequency (HFO) bands, and their phase amplitude coupling (PAC) in a large cohort in Parkinson’s disease (PD). Intra-operative local field potentials (LFPs) from subthalamic nucleus (STN) were recorded from 100 PD subjects, data from 74 subjects were included in the analysis. Alpha/beta oscillations were evident in >99%, HFO in 87% and PAC in 98% of cases. Alpha/beta oscillations (P < 0.01) and PAC were stronger in the more affected (MA) hemisphere (P = 0.03). Alpha/beta oscillations were primarily found in 13–20 Hz (low beta). Beta and HFO frequencies with the greatest coupling, were positively correlated (P = 0.001). Tremor attenuated alpha (P = 0.002) and beta band oscillations (P < 0.001). STN alpha/beta band oscillations and PAC were evident in ⩾98% cases and were greater in MA hemisphere. Resting tremor attenuated underlying alpha/beta band oscillations. Beta band LFP power may be used to drive adaptive deep brain stimulation (aDBS), augmented by a kinematic classifier in tremor dominant PD." @default.
• W2550671199 created "2016-11-30" @default.
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• W2550671199 date "2017-01-01" @default.
• W2550671199 modified "2023-10-17" @default.
• W2550671199 title "Subthalamic oscillations and phase amplitude coupling are greater in the more affected hemisphere in Parkinson’s disease" @default.
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• W2550671199 doi "https://doi.org/10.1016/j.clinph.2016.10.095" @default.
• W2550671199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27889627" @default.
• W2550671199 hasPublicationYear "2017" @default.
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