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- W2550677160 abstract "Background: The clinical utility of serum periostin and blood eosinophils to guide type 2 targeted treatment depends on the generalizability across demographics and other factors impacting the levels. Aims: To investigate the impact of demographics and comorbidities on periostin and eosinophil levels. Methods: The influence of baseline characteristics and comorbidities on periostin and eosinophils were examined in baseline samples from asthma patients included in the global phase 3 lebrikizumab trials (n=2149). Periostin was measured using the Elecsys Periostin assay (Roche Diagnostics). Eosinophil counts were centrally measured as part of a complete blood count. Thresholds for meaningful differences were established using the intrapatient variability over time (natural variation). A univariate model for a single biomarker was used to assess the relative change from a reference category, followed by a multivariate model including all variables showing an impact in the univariate model. Results: The natural variation was greater for eosinophils (±20%) than for periostin (±8%). After adjusting for all factors included in the multivariate analysis, nasal polyps (+22%), Asian race (+17%), South American region (+18%) and BMI≥30 (-9%) impacted periostin levels. Eosinophil levels were impacted by nasal polyps (+38%). Conclusion: Periostin levels are impacted by race, region, BMI and presence of nasal polyps. Despite the broad natural variation for eosinophils, which precluded meaningful interpretation of factors impacting eosinophil levels, eosinophil levels were higher in patients with nasal polyps than without. These factors might need to be taken into account when using these biomarkers for treatment guidance." @default.
- W2550677160 created "2016-11-30" @default.
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- W2550677160 date "2016-09-01" @default.
- W2550677160 modified "2023-09-24" @default.
- W2550677160 title "LATE-BREAKING ABSTRACT: Impact of demographics and comorbidities on periostin and eosinophil levels" @default.
- W2550677160 doi "https://doi.org/10.1183/13993003.congress-2016.oa4950" @default.
- W2550677160 hasPublicationYear "2016" @default.
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