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- W2550735898 abstract "Background: Bronchial thermoplasty (BT) improves asthma symptoms by reducing the airway smooth muscle (ASM) mass. A durable efficacy and safety of BT on asthma control has been documented out to 5 years in patients with severe persistent asthma. The ASM reduction has been demonstrated in bronchial biopsies taken 3 weeks or 3 months post-BT. BT also decreased type 1 collagen deposition and sub-epithelial basement membrane thickening. The persistence of these structural changes over time with durable clinical benefits observed in clinical trials remains uncertain. Objectives: To assess long-term efficacy of BT on ASM mass and sub-epithelial collagen deposition. Methods: Nine subjects (age: 30-70 years; FEV1: 60-105% of predicted; ICS: 500-1500µg fluticasone equivalent) with persistent asthma underwent BT procedures. Bronchial biopsies were taken before (baseline), and at 3-14 weeks and 27-48 months after BT. Histology and immunohistochemistry studies were performed. Clinical evaluation was performed at 12 and ≥27 months post-BT. Results: ASM area decreased from 11.8% ±1.24% at baseline to 4.7± 0.95% at week 3 post BT and this decrease persisted at ≥27 months post-BT: 4.6±1.05%, P=0.0002 compared to baseline. The type I collagen deposition decreased from 6.7±0.4 µm at baseline to 4.5±0.5 µm 3 weeks post-BT and remained unchanged at long-term followup: 4.6±0.5 µm (P=0.003). At 12 and ≥27 months, BT improved significantly the Asthma Control Scoring Score compared to baseline and decreased the number of severe exacerbations. Conclusion: These data showed long-term (≥27 months) benefits from BT in terms of ASM mass reduction, sub-epithelial collagen deposition and asthma control." @default.
- W2550735898 created "2016-11-30" @default.
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- W2550735898 date "2016-09-01" @default.
- W2550735898 modified "2023-09-27" @default.
- W2550735898 title "Long-term effects of bronchial thermoplasty on airway smooth muscle and collagen deposition in severe asthma" @default.
- W2550735898 doi "https://doi.org/10.1183/13993003.congress-2016.oa1794" @default.
- W2550735898 hasPublicationYear "2016" @default.
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