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• W2550797439 endingPage "9688" @default.
• W2550797439 startingPage "9680" @default.
• W2550797439 abstract "The polyketide synthase gene An15g07920 was known in Aspergillus niger CBS 513.88 as putatively involved in the production of ochratoxin A (OTA). Genome resequencing analysis revealed that the gene An15g07920 is also present in the ochratoxin-producing A. niger strain 1062. Disruption of An15g07920 in A. niger 1062 removed its capacity to biosynthesize ochratoxin β (OTβ), ochratoxin α (OTα), and OTA. These results indicate that the polyketide synthase encoded by An15g07920 is a crucial player in the biosynthesis of OTA, in the pathway prior to the phenylalanine ligation step. The gene An15g07920 reached its maximum transcription level before OTA accumulation reached its highest level, confirming that gene transcription precedes OTA production. These findings will not only help explain the mechanism of OTA production in A. niger but also provide necessary information for the development of effective diagnostic, preventive, and control strategies to reduce the risk of OTA contamination in foods." @default.
• W2550797439 created "2016-11-30" @default.
• W2550797439 creator A5037432321 @default.
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• W2550797439 date "2016-12-13" @default.
• W2550797439 modified "2023-10-17" @default.
• W2550797439 title "A Polyketide Synthase Encoded by the Gene An15g07920 Is Involved in the Biosynthesis of Ochratoxin A in <i>Aspergillus niger</i>" @default.
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• W2550797439 doi "https://doi.org/10.1021/acs.jafc.6b03907" @default.
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• W2550797439 hasPublicationYear "2016" @default.
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