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• W2550813738 abstract "Ruijs-Aalfs syndrome is a segmental progeroid syndrome resulting from mutations in the SPRTN gene. Cells derived from patients with SPRTN mutations elicit genomic instability and people afflicted with this syndrome developed hepatocellular carcinoma. Here we describe the molecular mechanism by which SPRTN contributes to genome stability and normal cellular homeostasis. We show that SPRTN is a DNA-dependent mammalian protease required for resolving cytotoxic DNA-protein crosslinks (DPCs)— a function that had only been attributed to the metalloprotease Wss1 in budding yeast. We provide genetic evidence that SPRTN and Wss1 function distinctly in vivo to resolve DPCs. Upon DNA and ubiquitin binding, SPRTN can elicit proteolytic activity; cleaving DPC substrates and itself. SPRTN null cells or cells derived from patients with Ruijs-Aalfs syndrome are impaired in the resolution of covalent DPCs in vivo. Collectively, SPRTN is a mammalian protease required for resolving DNA-protein crosslinks in vivo whose function is compromised in Ruijs-Aalfs syndrome patients." @default.
• W2550813738 created "2016-11-30" @default.
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• W2550813738 date "2016-11-17" @default.
• W2550813738 modified "2023-10-10" @default.
• W2550813738 title "SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks" @default.
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• W2550813738 doi "https://doi.org/10.7554/elife.21491" @default.
• W2550813738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5127644" @default.
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