Matches in SemOpenAlex for { <https://semopenalex.org/work/W2550866495> ?p ?o ?g. }
- W2550866495 abstract "Abstract Various folk remedies employ certain odorous compounds with analgesic effects. In fact, linalool, a monoterpene alcohol found in lavender extracts, has been found to attenuate pain responses via subcutaneous, intraperitoneal, intrathecal, and oral administration. However, the analgesic effects of odorous compounds mediated by olfaction have not been thoroughly examined. We performed behavioural pain tests under odourant vapour exposure in mice. Among six odourant molecules examined, linalool significantly increased the pain threshold and attenuated pain behaviours. Olfactory bulb or epithelium lesion removed these effects, indicating that olfactory sensory input triggered the effects. Furthermore, immunohistochemical analysis revealed that linalool activated hypothalamic orexin neurons, one of the key mediators for pain processing. Formalin tests in orexin neuron-ablated and orexin peptide-deficient mice showed orexinergic transmission was essential for linalool odour-induced analgesia. Together, these findings reveal central analgesic circuits triggered by olfactory input in the mammalian brain and support a potential therapeutic approach for treating pain with linalool odour stimulation." @default.
- W2550866495 created "2016-11-30" @default.
- W2550866495 creator A5009666612 @default.
- W2550866495 creator A5010232061 @default.
- W2550866495 creator A5026246591 @default.
- W2550866495 creator A5041904453 @default.
- W2550866495 creator A5062625400 @default.
- W2550866495 creator A5071530183 @default.
- W2550866495 creator A5071870601 @default.
- W2550866495 creator A5088055837 @default.
- W2550866495 date "2016-11-15" @default.
- W2550866495 modified "2023-10-15" @default.
- W2550866495 title "Odour-induced analgesia mediated by hypothalamic orexin neurons in mice" @default.
- W2550866495 cites W1627229807 @default.
- W2550866495 cites W1965454331 @default.
- W2550866495 cites W1969056832 @default.
- W2550866495 cites W1971565531 @default.
- W2550866495 cites W1973298486 @default.
- W2550866495 cites W1975564021 @default.
- W2550866495 cites W1975659558 @default.
- W2550866495 cites W1977210112 @default.
- W2550866495 cites W1978172792 @default.
- W2550866495 cites W1980363663 @default.
- W2550866495 cites W1986655409 @default.
- W2550866495 cites W1987808699 @default.
- W2550866495 cites W1990523428 @default.
- W2550866495 cites W1996757295 @default.
- W2550866495 cites W1998080960 @default.
- W2550866495 cites W2001933690 @default.
- W2550866495 cites W2004551214 @default.
- W2550866495 cites W2004745837 @default.
- W2550866495 cites W2008099612 @default.
- W2550866495 cites W2019224695 @default.
- W2550866495 cites W2021461388 @default.
- W2550866495 cites W2022180074 @default.
- W2550866495 cites W2024348439 @default.
- W2550866495 cites W2026720425 @default.
- W2550866495 cites W2027740042 @default.
- W2550866495 cites W2032166342 @default.
- W2550866495 cites W2040119896 @default.
- W2550866495 cites W2041519359 @default.
- W2550866495 cites W2054082584 @default.
- W2550866495 cites W2055066795 @default.
- W2550866495 cites W2058070208 @default.
- W2550866495 cites W2059590497 @default.
- W2550866495 cites W2059612424 @default.
- W2550866495 cites W2062700118 @default.
- W2550866495 cites W2064442671 @default.
- W2550866495 cites W2072154498 @default.
- W2550866495 cites W2074690643 @default.
- W2550866495 cites W2086672338 @default.
- W2550866495 cites W2086781134 @default.
- W2550866495 cites W2088683163 @default.
- W2550866495 cites W2091871334 @default.
- W2550866495 cites W2092804224 @default.
- W2550866495 cites W2092885293 @default.
- W2550866495 cites W2098848290 @default.
- W2550866495 cites W2100403768 @default.
- W2550866495 cites W2104700894 @default.
- W2550866495 cites W2115902692 @default.
- W2550866495 cites W2144249632 @default.
- W2550866495 cites W2152807333 @default.
- W2550866495 cites W2159953069 @default.
- W2550866495 cites W2164866920 @default.
- W2550866495 cites W2169136956 @default.
- W2550866495 cites W2172082745 @default.
- W2550866495 cites W2284948075 @default.
- W2550866495 cites W4231815232 @default.
- W2550866495 cites W4239384955 @default.
- W2550866495 doi "https://doi.org/10.1038/srep37129" @default.
- W2550866495 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5109046" @default.
- W2550866495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27845440" @default.
- W2550866495 hasPublicationYear "2016" @default.
- W2550866495 type Work @default.
- W2550866495 sameAs 2550866495 @default.
- W2550866495 citedByCount "32" @default.
- W2550866495 countsByYear W25508664952017 @default.
- W2550866495 countsByYear W25508664952018 @default.
- W2550866495 countsByYear W25508664952019 @default.
- W2550866495 countsByYear W25508664952020 @default.
- W2550866495 countsByYear W25508664952021 @default.
- W2550866495 countsByYear W25508664952022 @default.
- W2550866495 countsByYear W25508664952023 @default.
- W2550866495 crossrefType "journal-article" @default.
- W2550866495 hasAuthorship W2550866495A5009666612 @default.
- W2550866495 hasAuthorship W2550866495A5010232061 @default.
- W2550866495 hasAuthorship W2550866495A5026246591 @default.
- W2550866495 hasAuthorship W2550866495A5041904453 @default.
- W2550866495 hasAuthorship W2550866495A5062625400 @default.
- W2550866495 hasAuthorship W2550866495A5071530183 @default.
- W2550866495 hasAuthorship W2550866495A5071870601 @default.
- W2550866495 hasAuthorship W2550866495A5088055837 @default.
- W2550866495 hasBestOaLocation W25508664951 @default.
- W2550866495 hasConcept C118303440 @default.
- W2550866495 hasConcept C126322002 @default.
- W2550866495 hasConcept C134018914 @default.
- W2550866495 hasConcept C15490471 @default.
- W2550866495 hasConcept C170493617 @default.
- W2550866495 hasConcept C185592680 @default.
- W2550866495 hasConcept C2777278459 @default.