FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2550881869> ?p ?o ?g. }

• W2550881869 endingPage "393" @default.
• W2550881869 startingPage "386" @default.
• W2550881869 abstract "Purpose: To evaluate the effect of fractionated irradiation (FI) on tumor cells’ sensitivity to ionizing radiation (IR) and antineoplastic drugs, and examine the potential of early growth response-1 (EGR-1) inhibition to sensitize tumor cells to IR.Materials and methods: PC3 and HepG2 cells were subjected 10 times to γ-rays at 2 Gy. The surviving cells were named PC3/R and HepG2/R, respectively. The cells’ sensitivity to irradiation and chemotherapeutic drugs, including cisplatin (PT), doxorubicin (DOX), mitomycin C (MMC) and 5-fluorouracil (5-FU), were identified by colony formation assay and MMT method, respectively. Quantitative real-time polymerase chain reaction (RT-qPCR) analysis was utilized to compare the difference of gene expression between radioresistant cells and parental cells. The small interfering RNA system was implemented to inhibit endogenous EGR-1 expression in radiation-resistant cells. Western blot was employed to identify the possible mechanism by which EGR-1 regulates cells’ radiosensitivity.Results: FI induced cross-resistant to IR and MMC in tumor cells. Along with the reduction of ovarian cancer-2/disabled homolog 2 (DOC-2/DAB2) interactive protein (DAB2IP) expression, EGR-1 gene was upregulated in FI-treated cells. On the other hand, downregulation of EGR-1 gene expression sensitized radioresistant cells to IR accompanied by DAB2IP overexpression and STAT3 inactivation. In addition, NF-κB inhibitor, BAY11-7082 enhanced resistant cells’ radiosensitivity and chemosensitivity.Conclusions: Conventionally FI has a higher risk of forming acquired radioresistance (ARR) in vitro. EGR-1 gene-targeted drug design could be an effective strategy to overcome DAB2IP-dysregulation-induced ARR in tumor patients." @default.
• W2550881869 created "2016-11-30" @default.
• W2550881869 creator A5008580821 @default.
• W2550881869 creator A5050350085 @default.
• W2550881869 creator A5059018661 @default.
• W2550881869 creator A5082869420 @default.
• W2550881869 date "2016-12-07" @default.
• W2550881869 modified "2023-09-27" @default.
• W2550881869 title "Upregulating DAB2IP expression via EGR-1 inhibition, a new approach for overcoming fractionated-irradiation-induced cross-tolerance to ionizing radiation and mitomycin C in tumor cells" @default.
• W2550881869 cites W1789241753 @default.
• W2550881869 cites W1958891405 @default.
• W2550881869 cites W1967347847 @default.
• W2550881869 cites W1976878784 @default.
• W2550881869 cites W1983918795 @default.
• W2550881869 cites W1984428177 @default.
• W2550881869 cites W1992887797 @default.
• W2550881869 cites W1993060180 @default.
• W2550881869 cites W1994423181 @default.
• W2550881869 cites W2000097339 @default.
• W2550881869 cites W2002782368 @default.
• W2550881869 cites W2003577093 @default.
• W2550881869 cites W2018334084 @default.
• W2550881869 cites W2028614554 @default.
• W2550881869 cites W2044151404 @default.
• W2550881869 cites W2074500644 @default.
• W2550881869 cites W2092368761 @default.
• W2550881869 cites W2117420591 @default.
• W2550881869 cites W2117535432 @default.
• W2550881869 cites W2121485022 @default.
• W2550881869 cites W2151010413 @default.
• W2550881869 cites W2156178552 @default.
• W2550881869 cites W2111106826 @default.
• W2550881869 doi "https://doi.org/10.1080/09553002.2016.1257831" @default.
• W2550881869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27834104" @default.
• W2550881869 hasPublicationYear "2016" @default.
• W2550881869 type Work @default.
• W2550881869 sameAs 2550881869 @default.
• W2550881869 citedByCount "5" @default.
• W2550881869 countsByYear W25508818692020 @default.
• W2550881869 countsByYear W25508818692022 @default.
• W2550881869 countsByYear W25508818692023 @default.
• W2550881869 crossrefType "journal-article" @default.
• W2550881869 hasAuthorship W2550881869A5008580821 @default.
• W2550881869 hasAuthorship W2550881869A5050350085 @default.
• W2550881869 hasAuthorship W2550881869A5059018661 @default.
• W2550881869 hasAuthorship W2550881869A5082869420 @default.
• W2550881869 hasConcept C104317684 @default.
• W2550881869 hasConcept C111337013 @default.
• W2550881869 hasConcept C117262875 @default.
• W2550881869 hasConcept C119056186 @default.
• W2550881869 hasConcept C121332964 @default.
• W2550881869 hasConcept C121608353 @default.
• W2550881869 hasConcept C126322002 @default.
• W2550881869 hasConcept C127561419 @default.
• W2550881869 hasConcept C153911025 @default.
• W2550881869 hasConcept C18231593 @default.
• W2550881869 hasConcept C185544564 @default.
• W2550881869 hasConcept C202751555 @default.
• W2550881869 hasConcept C206684579 @default.
• W2550881869 hasConcept C26114605 @default.
• W2550881869 hasConcept C2776415932 @default.
• W2550881869 hasConcept C2776694085 @default.
• W2550881869 hasConcept C2778239845 @default.
• W2550881869 hasConcept C2779338040 @default.
• W2550881869 hasConcept C502942594 @default.
• W2550881869 hasConcept C509974204 @default.
• W2550881869 hasConcept C54009773 @default.
• W2550881869 hasConcept C54355233 @default.
• W2550881869 hasConcept C55493867 @default.
• W2550881869 hasConcept C58962609 @default.
• W2550881869 hasConcept C71924100 @default.
• W2550881869 hasConcept C81885089 @default.
• W2550881869 hasConcept C86803240 @default.
• W2550881869 hasConcept C96232424 @default.
• W2550881869 hasConceptScore W2550881869C104317684 @default.
• W2550881869 hasConceptScore W2550881869C111337013 @default.
• W2550881869 hasConceptScore W2550881869C117262875 @default.
• W2550881869 hasConceptScore W2550881869C119056186 @default.
• W2550881869 hasConceptScore W2550881869C121332964 @default.
• W2550881869 hasConceptScore W2550881869C121608353 @default.
• W2550881869 hasConceptScore W2550881869C126322002 @default.
• W2550881869 hasConceptScore W2550881869C127561419 @default.
• W2550881869 hasConceptScore W2550881869C153911025 @default.
• W2550881869 hasConceptScore W2550881869C18231593 @default.
• W2550881869 hasConceptScore W2550881869C185544564 @default.
• W2550881869 hasConceptScore W2550881869C202751555 @default.
• W2550881869 hasConceptScore W2550881869C206684579 @default.
• W2550881869 hasConceptScore W2550881869C26114605 @default.
• W2550881869 hasConceptScore W2550881869C2776415932 @default.
• W2550881869 hasConceptScore W2550881869C2776694085 @default.
• W2550881869 hasConceptScore W2550881869C2778239845 @default.
• W2550881869 hasConceptScore W2550881869C2779338040 @default.
• W2550881869 hasConceptScore W2550881869C502942594 @default.
• W2550881869 hasConceptScore W2550881869C509974204 @default.
• W2550881869 hasConceptScore W2550881869C54009773 @default.
• W2550881869 hasConceptScore W2550881869C54355233 @default.
• W2550881869 hasConceptScore W2550881869C55493867 @default.
• W2550881869 hasConceptScore W2550881869C58962609 @default.

• next