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- W2550954885 abstract "Background: Urinary excretion of angiotensinogen (UAGT) has been proposed as a biomarker of intrarenal renin-angiotensin system activity. Objective: We investigated the association between UAGT and salt- and potassium-sensitivity of blood pressure (BP) among Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study participants. Method: The intervention consisted of a 7-day low-sodium diet (51.3 mmol sodium/day), 7-day high-sodium diet (307.8 mmol sodium/day), and 7-day high sodium diet with potassium supplementation (307.8 mmol sodium and 60 mmol potassium/day). 24-hour UAGT was estimated at baseline and at the end of each intervention for 100 randomly selected participants. Result: Median UAGT (μg/24 hours) and UAGT-to-creatinine ratio (UAGT/Cr, μg/g) were significantly reduced during low-sodium and potassium supplementation interventions and increased during high-sodium intervention (both p = 0.01). Baseline log-transformed UAGT and UAGT/Cr ratio were significantly positively associated with BP at baseline and at the end of each intervention. For example, one standard deviation higher log-UAGT/Cr ratio (1.2 μg/g) was associated with a 5.0 mmHg (95% confidence interval: 2.3, 7.8) higher systolic BP at the end of the high-sodium intervention, after adjusting for multiple covariates (p = 0.003). In addition, one standard deviation higher log-UAGT/Cr ratio was associated with a 1.6 mmHg increase in age- and sex-adjusted systolic BP from the low-sodium intervention to the high-sodium intervention (95% confidence interval: 0.1, 3.1; p = 0.04). This association was no longer statistically significant after multivariable adjustment. Conclusion: These data indicate that elevated UAGT are associated with BP sodium-sensitivity. Augmentation of intrarenal renin-angiotensin system activity may play an important role in developing salt-sensitive hypertension." @default.
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- W2550954885 date "2015-06-01" @default.
- W2550954885 modified "2023-10-14" @default.
- W2550954885 title "Urine Angiotensinogen and Salt- and Potassium-Sensitivity of Blood Pressure" @default.
- W2550954885 doi "https://doi.org/10.1097/01.hjh.0000469731.90492.8a" @default.
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