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• W2550991567 abstract "Targeting Polymerase-1 (POL1) transcription machinery is a new strategy for suppression of multiple sclerosis (MS) disease activity that is based on suppression of ribosomal biogenesis and subsequent activation of apoptosis. We developed an oral POL1 inhibiting compound RAM-589.555, that suppress ribosomal biogenesis as an innovative therapeutic approach to ameliorate MS. RAM-589.555 shows high permeability, specificity to POL1 pathway, ability to induce apoptosis and to inhibit proliferation and viability of activated lymphocytes both in-vitro and in-vivo. Moreover, oral administration of RAM-589.555 blocks ribosomal RNA transcription and significantly suppresses and ameliorates experimental autoimmune encephalomyelitis (EAE)." @default.
• W2550991567 created "2016-11-30" @default.
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• W2550991567 date "2017-01-01" @default.
• W2550991567 modified "2023-09-28" @default.
• W2550991567 title "RAM-589.555 a new Polymerase-1 inhibitor as innovative targeted-treatment for multiple sclerosis" @default.
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• W2550991567 doi "https://doi.org/10.1016/j.jneuroim.2016.10.016" @default.
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