Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551036627> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2551036627 endingPage "1746" @default.
- W2551036627 startingPage "1746" @default.
- W2551036627 abstract "Abstract Abstract 1746 Introduction: Systemic Mastocytosis (SM) is a myeloproliferative neoplasm (MPN) with heterogeneous clinical manifestations and limited treatment options for patients with aggressive disease. The WHO Classification sub divides SM patients into Indolent (ISM: evidence of clonal mast cells in bone marrow), Smouldering (SSM: Trypstase > 200ng/ml;organomegaly without dysfunction; bone marrow mast cell burden > 30% ), Aggressive (ASM: organomegaly with laboratory evidence of dysfunction), Mast Cell Leukaemia (MCL; > 20% mast cells on aspirate and >10% on blood film) and Associated Haematological Non-Mast Cell Disorders (AHNMD). The c-kit mutation (D816V) is present in > 90% of SM patients. Tryptase levels reflect total mast cell burden. To date there is no discriminatory marker to allow for identification of SM patients with more aggressive disease. CD30 (Ki-I antigen) has been reported as a potential marker for mast cells in high grade mastocytosis (Sotlar et al, 2011).We present preliminary data on 43 SM patients seen at Guys and St Thomas' Hospitals NHS Foundation Trust looking at CD30 and CD123 expression with clinical correlates. Methodology: 43/58 SM patients who have a full set of clinical records and bone marrow trephine samples have been evaluated. Bone marrow trephine processing: fixation in a neutral buffered formalin < 24hours; EDTA decalcification for 48 hours;Immunochemistry on an automated immunostainer (Leica Bondmax)using standard protocols: CD 30 (Dako dilution 1:75, antigen retrieval ER2). CD123 (BD Sciences, Novacastra, dilution 1:400,antigen retrieval ER2). Bone Marrow trephine samples were reviewed by haematopathologists at diagnostic MDM. Disease bulk was estimated as a percentage of the trephine sample. Immunocytochemistry review of the CD30/CD123 was reviewed by a single haematopathologist for this study. Clinical information was reviewed for laboratory results, tryptase levels, clinical symptoms and SM diagnosis. Results: 43 patients: M:F(18:25). SM diagnoses: 26 ISM (60%), 2 SSM (5%),3 ASM (7% ), 12 AHNMD (28%). Data on 43 patients for CD30 expression and 40 for CD123 expression. Tryptase: 20 CD30(+) patients median 74.9ng/ml (range 16.6–285ng/ml): 23 CD 30(−) patients median 43.6ng/ml (range 15.1–386ng/ml). Conclusions: Our preliminary data on 43 patients with SM/ CD30/123 expression suggests: Disclosures: Harrison: Novartis: Honoraria, Research Funding, Speakers Bureau; YM Bioscience: Consultancy, Honoraria; Sanofi Aventis: Honoraria; Shire: Honoraria, Research Funding." @default.
- W2551036627 created "2016-11-30" @default.
- W2551036627 creator A5014412007 @default.
- W2551036627 creator A5028061272 @default.
- W2551036627 creator A5046827092 @default.
- W2551036627 creator A5061273153 @default.
- W2551036627 creator A5071978632 @default.
- W2551036627 creator A5085946757 @default.
- W2551036627 date "2012-11-16" @default.
- W2551036627 modified "2023-10-16" @default.
- W2551036627 title "CD30/CD123 Expression in Systemic Mastocytosis Does Not Correlate with Aggressive Disease" @default.
- W2551036627 doi "https://doi.org/10.1182/blood.v120.21.1746.1746" @default.
- W2551036627 hasPublicationYear "2012" @default.
- W2551036627 type Work @default.
- W2551036627 sameAs 2551036627 @default.
- W2551036627 citedByCount "7" @default.
- W2551036627 countsByYear W25510366272014 @default.
- W2551036627 countsByYear W25510366272015 @default.
- W2551036627 countsByYear W25510366272018 @default.
- W2551036627 countsByYear W25510366272020 @default.
- W2551036627 crossrefType "journal-article" @default.
- W2551036627 hasAuthorship W2551036627A5014412007 @default.
- W2551036627 hasAuthorship W2551036627A5028061272 @default.
- W2551036627 hasAuthorship W2551036627A5046827092 @default.
- W2551036627 hasAuthorship W2551036627A5061273153 @default.
- W2551036627 hasAuthorship W2551036627A5071978632 @default.
- W2551036627 hasAuthorship W2551036627A5085946757 @default.
- W2551036627 hasConcept C126322002 @default.
- W2551036627 hasConcept C142724271 @default.
- W2551036627 hasConcept C203014093 @default.
- W2551036627 hasConcept C2776232749 @default.
- W2551036627 hasConcept C2778551932 @default.
- W2551036627 hasConcept C2779134260 @default.
- W2551036627 hasConcept C2779726688 @default.
- W2551036627 hasConcept C2780007613 @default.
- W2551036627 hasConcept C2780076729 @default.
- W2551036627 hasConcept C2780581156 @default.
- W2551036627 hasConcept C2781107747 @default.
- W2551036627 hasConcept C2781406822 @default.
- W2551036627 hasConcept C2909606595 @default.
- W2551036627 hasConcept C71924100 @default.
- W2551036627 hasConceptScore W2551036627C126322002 @default.
- W2551036627 hasConceptScore W2551036627C142724271 @default.
- W2551036627 hasConceptScore W2551036627C203014093 @default.
- W2551036627 hasConceptScore W2551036627C2776232749 @default.
- W2551036627 hasConceptScore W2551036627C2778551932 @default.
- W2551036627 hasConceptScore W2551036627C2779134260 @default.
- W2551036627 hasConceptScore W2551036627C2779726688 @default.
- W2551036627 hasConceptScore W2551036627C2780007613 @default.
- W2551036627 hasConceptScore W2551036627C2780076729 @default.
- W2551036627 hasConceptScore W2551036627C2780581156 @default.
- W2551036627 hasConceptScore W2551036627C2781107747 @default.
- W2551036627 hasConceptScore W2551036627C2781406822 @default.
- W2551036627 hasConceptScore W2551036627C2909606595 @default.
- W2551036627 hasConceptScore W2551036627C71924100 @default.
- W2551036627 hasIssue "21" @default.
- W2551036627 hasLocation W25510366271 @default.
- W2551036627 hasOpenAccess W2551036627 @default.
- W2551036627 hasPrimaryLocation W25510366271 @default.
- W2551036627 hasRelatedWork W2018365077 @default.
- W2551036627 hasRelatedWork W2020702471 @default.
- W2551036627 hasRelatedWork W2046616500 @default.
- W2551036627 hasRelatedWork W2482969765 @default.
- W2551036627 hasRelatedWork W2551036627 @default.
- W2551036627 hasRelatedWork W2755136843 @default.
- W2551036627 hasRelatedWork W2843095124 @default.
- W2551036627 hasRelatedWork W2942099139 @default.
- W2551036627 hasRelatedWork W3025830589 @default.
- W2551036627 hasRelatedWork W4323821339 @default.
- W2551036627 hasVolume "120" @default.
- W2551036627 isParatext "false" @default.
- W2551036627 isRetracted "false" @default.
- W2551036627 magId "2551036627" @default.
- W2551036627 workType "article" @default.