Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551078588> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2551078588 abstract "Background Our previous data [1],[2],[3] showed that renal artery stenosis (RAS) is more prevalent in antiphospholipid syndrome (APS) (26%) compared to the general hypertensive population (8%),and anticoagulation with INR≥3 was associated with initial reduction of chronic kidney disease (CKD) and hypertension. Objectives To characterise the long-term outcomes and associations with anticoagulant treatment for patients with renal artery stenosis and antiphospholipid syndrome. Methods We identified 37 patients with RAS and APS fulfilling Sapporo criteria [4]: anticardiolipin IgG/IgM titer>40 units or >99th percentile (or +lupus anticoagulant) on ≥2 occasions ≥6 weeks apart AND vascular thrombosis (or pregnancy morbidity). RAS was diagnosed by magnetic resonance angiography (MRA). Results 15 patients had APS alone and 22 APS associated with autoimmune conditions (13 lupus, 5 ANCA vasculitis, 4 mixed). Median age at RAS diagnosis was 48 years, 31/37 (83.8%) were female and median follow-up was 10.4 years. 25/37 (67.6%) had previous thrombosis. 7/37 (18.9%) had bilateral RAS, 3 artery occlusion. 6/37 (16.2%) had concurrent coeliac stenosis. Recanalization of RAS occurred after hydroxychloroquine in 3/37 and 9/37 (24.3%) underwent angioplasty +/− stenting. MRA was repeated in 11/37 (29.7%) after 2 years. 23/37 (62.2%) were anticoagulated, with 9/37 (24.3%) on antiplatelet therapy. 13/37 (35.1%) received hydroxychloroquine, 10/22 (45.5%) immunosuppressives and 18/37 (48.6%) antihypertensives. 9/37 (24.3%) died after a median of 10 years since RAS diagnosis. 21/37 (56.8%) developed CKD: 6 endstage renal failure (ESRD) and 15 with median eGFR 39 mls/min. Conclusions The majority of patients with RAS and APS were female, developed CKD and did not benefit from renal angioplasty. Anticoagulation was not associated with longterm reduction of ESRD or death, suggesting a non-thrombotic pathogenic process underlying RAS, such as intimal hyperplasia. Treatment of associated vascular risk factors and autoimmune disease is paramount. Anticardiolipin antibodies and renal MRA are useful screening tests for lupus patients with difficult blood pressure control. References S R Sangle, D P D9Cruz et al. Ann Rheum Dis 2003;62:999–1002. S R Sangle, D P D9Cruz et al. Rheumatology 2005;44:372–37 Jordan NP, Chaib A, Sangle S, D9Cruz DP. Arthritis Care and Research) 2013 Sipek-Dolnicar A, Hojnik M, Bozic B, Vizjak A. Clin Exp Rheumatol. 2002; 20:335–42. Disclosure of Interest None declared" @default.
- W2551078588 created "2016-11-30" @default.
- W2551078588 creator A5011432218 @default.
- W2551078588 creator A5038428544 @default.
- W2551078588 creator A5049326244 @default.
- W2551078588 creator A5053862940 @default.
- W2551078588 creator A5064706028 @default.
- W2551078588 date "2016-06-01" @default.
- W2551078588 modified "2023-09-27" @default.
- W2551078588 title "THU0283 Anticoagulation and Long-Term Outcomes in Patients with Renal Artery Stenosis and Antiphospholipid Syndrome:" @default.
- W2551078588 doi "https://doi.org/10.1136/annrheumdis-2016-eular.2391" @default.
- W2551078588 hasPublicationYear "2016" @default.
- W2551078588 type Work @default.
- W2551078588 sameAs 2551078588 @default.
- W2551078588 citedByCount "0" @default.
- W2551078588 crossrefType "journal-article" @default.
- W2551078588 hasAuthorship W2551078588A5011432218 @default.
- W2551078588 hasAuthorship W2551078588A5038428544 @default.
- W2551078588 hasAuthorship W2551078588A5049326244 @default.
- W2551078588 hasAuthorship W2551078588A5053862940 @default.
- W2551078588 hasAuthorship W2551078588A5064706028 @default.
- W2551078588 hasConcept C126322002 @default.
- W2551078588 hasConcept C126838900 @default.
- W2551078588 hasConcept C141071460 @default.
- W2551078588 hasConcept C143409427 @default.
- W2551078588 hasConcept C164705383 @default.
- W2551078588 hasConcept C2776634560 @default.
- W2551078588 hasConcept C2776874634 @default.
- W2551078588 hasConcept C2778212899 @default.
- W2551078588 hasConcept C2778653478 @default.
- W2551078588 hasConcept C2779123688 @default.
- W2551078588 hasConcept C2779134260 @default.
- W2551078588 hasConcept C2780022809 @default.
- W2551078588 hasConcept C2780091579 @default.
- W2551078588 hasConcept C2780326628 @default.
- W2551078588 hasConcept C2780868729 @default.
- W2551078588 hasConcept C2781016617 @default.
- W2551078588 hasConcept C2908647359 @default.
- W2551078588 hasConcept C3008058167 @default.
- W2551078588 hasConcept C524204448 @default.
- W2551078588 hasConcept C71924100 @default.
- W2551078588 hasConcept C90924648 @default.
- W2551078588 hasConcept C99454951 @default.
- W2551078588 hasConceptScore W2551078588C126322002 @default.
- W2551078588 hasConceptScore W2551078588C126838900 @default.
- W2551078588 hasConceptScore W2551078588C141071460 @default.
- W2551078588 hasConceptScore W2551078588C143409427 @default.
- W2551078588 hasConceptScore W2551078588C164705383 @default.
- W2551078588 hasConceptScore W2551078588C2776634560 @default.
- W2551078588 hasConceptScore W2551078588C2776874634 @default.
- W2551078588 hasConceptScore W2551078588C2778212899 @default.
- W2551078588 hasConceptScore W2551078588C2778653478 @default.
- W2551078588 hasConceptScore W2551078588C2779123688 @default.
- W2551078588 hasConceptScore W2551078588C2779134260 @default.
- W2551078588 hasConceptScore W2551078588C2780022809 @default.
- W2551078588 hasConceptScore W2551078588C2780091579 @default.
- W2551078588 hasConceptScore W2551078588C2780326628 @default.
- W2551078588 hasConceptScore W2551078588C2780868729 @default.
- W2551078588 hasConceptScore W2551078588C2781016617 @default.
- W2551078588 hasConceptScore W2551078588C2908647359 @default.
- W2551078588 hasConceptScore W2551078588C3008058167 @default.
- W2551078588 hasConceptScore W2551078588C524204448 @default.
- W2551078588 hasConceptScore W2551078588C71924100 @default.
- W2551078588 hasConceptScore W2551078588C90924648 @default.
- W2551078588 hasConceptScore W2551078588C99454951 @default.
- W2551078588 hasLocation W25510785881 @default.
- W2551078588 hasOpenAccess W2551078588 @default.
- W2551078588 hasPrimaryLocation W25510785881 @default.
- W2551078588 hasRelatedWork W1575303134 @default.
- W2551078588 hasRelatedWork W1977255225 @default.
- W2551078588 hasRelatedWork W1987670691 @default.
- W2551078588 hasRelatedWork W1990439813 @default.
- W2551078588 hasRelatedWork W2003743657 @default.
- W2551078588 hasRelatedWork W2014368662 @default.
- W2551078588 hasRelatedWork W2018571672 @default.
- W2551078588 hasRelatedWork W2050809459 @default.
- W2551078588 hasRelatedWork W2186256480 @default.
- W2551078588 hasRelatedWork W2380281068 @default.
- W2551078588 hasRelatedWork W2381318468 @default.
- W2551078588 hasRelatedWork W2396328659 @default.
- W2551078588 hasRelatedWork W2550176330 @default.
- W2551078588 hasRelatedWork W2556672996 @default.
- W2551078588 hasRelatedWork W2576940945 @default.
- W2551078588 hasRelatedWork W2578061731 @default.
- W2551078588 hasRelatedWork W2736373532 @default.
- W2551078588 hasRelatedWork W2908507018 @default.
- W2551078588 hasRelatedWork W3035473172 @default.
- W2551078588 hasRelatedWork W3164401956 @default.
- W2551078588 isParatext "false" @default.
- W2551078588 isRetracted "false" @default.
- W2551078588 magId "2551078588" @default.
- W2551078588 workType "article" @default.