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- W2551132062 abstract "The cell-cell signaling mechanisms controlling mesenchymal stromal cell (MSC) behavior are often examined using heterogeneous cultures that may contain clonal cells of varying potencies alongside other stromal populations. This chapter discusses some of the key signaling pathways controlling MSC differentiation. Adult stem cells interact locally with their surrounding environment or niche, which is composed of a mixed community of stem cells and their differentiated progeny, niche-resident cells, and components of the extracellular matrix (ECM). The bone morphogenetic proteins (BMPs) were initially identified as a group of proteins that induce endochondral bone formation and are members of the TGF-β superfamily of signaling molecules. BMP signaling also plays a role in embryonic limb and digit development. Much research has focused on Wnt signaling since the discovery of mammalian Wnt1 and such efforts have determined roles for this pathway in the regulation of many cellular activities, including cell proliferation, differentiation, and migration." @default.
- W2551132062 created "2016-11-30" @default.
- W2551132062 creator A5038336713 @default.
- W2551132062 creator A5041638052 @default.
- W2551132062 creator A5044044819 @default.
- W2551132062 creator A5060339009 @default.
- W2551132062 date "2016-11-26" @default.
- W2551132062 modified "2023-10-14" @default.
- W2551132062 title "Cell–cell signaling pathways that regulate mesenchymal stromal cell differentiation" @default.
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