FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551142076> ?p ?o ?g. }

• W2551142076 endingPage "10" @default.
• W2551142076 startingPage "1" @default.
• W2551142076 abstract "Heart failure (HF) is a major killer with high morbidity and mortality and nearly 37.7 million people are affected by HF globally, making this a global epidemic. HF is a complex pathophysiological syndrome in which the mechanical function of heart for pumping blood is compromised. Cardiac structural and functional abnormalities culminate in decreased cardiac output along with increased intracardiac pressures under resting or stress conditions, leading to HF. Besides the acquired risk factors, the independent role of hereditary and genetic factors in the development, progression and prognosis of HF remains to be established. One of the most common causes of HF is cardiomyopathy and dilated cardiomyopathy and hypertrophic cardiomyopathy are the major forms, transmitted by autosomal dominant inheritance and often result from mutations in single or multiple genes, which predominantly code for proteins present in the cardiac sarcomere. Other inherited forms of cardiomyopathies that can trigger HF are metabolic and mitochondrial cardiomyopathies that result from mutations in proteins involved in fat or carbohydrate metabolism or mitochondrial biogenesis, affecting cardiomyocyte energy balance. Because of the inherent complications in the aetiology of HF, only a small number of genome-wide association studies (GWAS) could be conducted to identify SNPs in genes that are causally related to HF. Recent attempts to conduct GWAS in a focused approach on the HF risk factors led to identification of more SNPs. Initial attempts for gene therapy using adeno-associated viral vectors have not been successful, but more studies are needed to understand the pathophysiological and genetic basis of HF." @default.
• W2551142076 created "2016-11-30" @default.
• W2551142076 creator A5023935570 @default.
• W2551142076 creator A5067299655 @default.
• W2551142076 date "2016-11-21" @default.
• W2551142076 modified "2023-10-14" @default.
• W2551142076 title "Genetic determinants of myocardial dysfunction" @default.
• W2551142076 cites W113157475 @default.
• W2551142076 cites W145908001 @default.
• W2551142076 cites W1540912658 @default.
• W2551142076 cites W1576493459 @default.
• W2551142076 cites W1967476238 @default.
• W2551142076 cites W1971821609 @default.
• W2551142076 cites W1984606352 @default.
• W2551142076 cites W1985678297 @default.
• W2551142076 cites W1987683355 @default.
• W2551142076 cites W1991507611 @default.
• W2551142076 cites W1992644002 @default.
• W2551142076 cites W1993823264 @default.
• W2551142076 cites W1995846502 @default.
• W2551142076 cites W1996361830 @default.
• W2551142076 cites W2000949542 @default.
• W2551142076 cites W2004807060 @default.
• W2551142076 cites W2004835035 @default.
• W2551142076 cites W2011112539 @default.
• W2551142076 cites W2016553071 @default.
• W2551142076 cites W2017221955 @default.
• W2551142076 cites W2021493550 @default.
• W2551142076 cites W2025389038 @default.
• W2551142076 cites W2026187919 @default.
• W2551142076 cites W2037283919 @default.
• W2551142076 cites W2037865000 @default.
• W2551142076 cites W2038222921 @default.
• W2551142076 cites W2040686597 @default.
• W2551142076 cites W2043041585 @default.
• W2551142076 cites W2047834942 @default.
• W2551142076 cites W2051152155 @default.
• W2551142076 cites W2060835874 @default.
• W2551142076 cites W2061100095 @default.
• W2551142076 cites W2061884629 @default.
• W2551142076 cites W2070259852 @default.
• W2551142076 cites W2074804984 @default.
• W2551142076 cites W2076034570 @default.
• W2551142076 cites W207706498 @default.
• W2551142076 cites W2079759746 @default.
• W2551142076 cites W2081209712 @default.
• W2551142076 cites W2082173027 @default.
• W2551142076 cites W2084688599 @default.
• W2551142076 cites W2085689908 @default.
• W2551142076 cites W2094925535 @default.
• W2551142076 cites W2096322772 @default.
• W2551142076 cites W2097138831 @default.
• W2551142076 cites W2099221358 @default.
• W2551142076 cites W2101648125 @default.
• W2551142076 cites W2101818794 @default.
• W2551142076 cites W2102965772 @default.
• W2551142076 cites W2104038552 @default.
• W2551142076 cites W2105095326 @default.
• W2551142076 cites W2109712401 @default.
• W2551142076 cites W2110624042 @default.
• W2551142076 cites W2112484130 @default.
• W2551142076 cites W2115862827 @default.
• W2551142076 cites W2120426463 @default.
• W2551142076 cites W2126388596 @default.
• W2551142076 cites W2128788602 @default.
• W2551142076 cites W2129677512 @default.
• W2551142076 cites W2131062132 @default.
• W2551142076 cites W2133258097 @default.
• W2551142076 cites W2134109459 @default.
• W2551142076 cites W2135048894 @default.
• W2551142076 cites W2135302420 @default.
• W2551142076 cites W2140752009 @default.
• W2551142076 cites W2141561295 @default.
• W2551142076 cites W2145290472 @default.
• W2551142076 cites W2148910374 @default.
• W2551142076 cites W2149030597 @default.
• W2551142076 cites W2151341839 @default.
• W2551142076 cites W2151702576 @default.
• W2551142076 cites W2155789085 @default.
• W2551142076 cites W2156569889 @default.
• W2551142076 cites W2157887741 @default.
• W2551142076 cites W2160789215 @default.
• W2551142076 cites W2161501475 @default.
• W2551142076 cites W2162634302 @default.
• W2551142076 cites W2167989424 @default.
• W2551142076 cites W2168324813 @default.
• W2551142076 cites W2178738676 @default.
• W2551142076 cites W2227482793 @default.
• W2551142076 cites W2267314041 @default.
• W2551142076 cites W2269123435 @default.
• W2551142076 cites W2271175958 @default.
• W2551142076 cites W2282067660 @default.
• W2551142076 cites W2292493149 @default.
• W2551142076 cites W2316919104 @default.
• W2551142076 cites W2325990028 @default.
• W2551142076 cites W2345655181 @default.
• W2551142076 cites W2346049904 @default.
• W2551142076 cites W2419412629 @default.

• next