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- W2551241918 endingPage "125" @default.
- W2551241918 startingPage "95" @default.
- W2551241918 abstract "It is well established that chylomicron remnant (dietary) vitamin A is taken up from the circulation by hepatocytes, but more than 80 % of the vitamin A in the liver is stored in hepatic stellate cells (HSC). It presently is not known how vitamin A is transferred from hepatocytes to HSCs for storage. Since retinol-binding protein 4 (RBP4), a protein that is required for mobilizing stored vitamin A, is synthesized solely by hepatocytes and not HSCs, it similarly is not known how vitamin A is transferred from HSCs to hepatocytes. Although it has long been thought that RBP4 is absolutely essential for delivering vitamin A to tissues, recent research has proven that this notion is incorrect since total RBP4-deficiency is not lethal. In addition to RBP4, vitamin A is also found in the circulation bound to lipoproteins and as retinoic acid bound to albumin. It is not known how these different circulating pools of vitamin A contribute to the vitamin A needs of different tissues. In our view, better insight into these three issues is required to better understand vitamin A absorption, storage and mobilization. Here, we provide an up to date synthesis of current knowledge regarding the intestinal uptake of dietary vitamin A, the storage of vitamin A within the liver, and the mobilization of hepatic vitamin A stores, and summarize areas where our understanding of these processes is incomplete." @default.
- W2551241918 created "2016-11-30" @default.
- W2551241918 creator A5010752633 @default.
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- W2551241918 creator A5039291226 @default.
- W2551241918 creator A5039373859 @default.
- W2551241918 creator A5069241630 @default.
- W2551241918 date "2016-01-01" @default.
- W2551241918 modified "2023-10-15" @default.
- W2551241918 title "Vitamin A Absorption, Storage and Mobilization" @default.
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