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• W2551291254 abstract "// Wei Luo 1, * , Xiaonian Zhu 1, * , Wei Liu 1 , Yuan Ren 1 , Chunhua Bei 1 , Linyuan Qin 1 , Xueyan Miao 1 , Fen Tang 2 , Guifang Tang 2 , Shengkui Tan 1 1 School of Public Health, Guilin Medical University, Guilin 541004, Guangxi, People’s Republic of China 2 Department of Hepatology, The Affiliated Nanxishan Hospital of Guilin Medical University, Guilin 541004, Guangxi, People’s Republic of China * These authors contributed equally to this work Correspondence to: Shengkui Tan, email: sktan2008@sina.cn Keywords: MYC associated zinc finger protein (MAZ), hepatocellular carcinoma (HCC), zinc finger E-box binding homeobox 1 (ZEB1), zinc finger E-box binding homeobox 2 (ZEB2), epithelial-mesenchymal transition (EMT) Received: July 11, 2016      Accepted: November 09, 2016      Published: November 16, 2016 ABSTRACT MYC associated zinc finger protein (MAZ) plays a key role in regulation of gene expression and tumor development. Studies have shown that deregulated expression of MAZ is closely related to the progression of tumors such as glioblastoma, breast cancer, prostate cancer and liposarcoma. However, the role of MAZ in hepatocellular carcinoma (HCC) has not been fully elucidated. Here, we found that expression of MAZ was increased in HCC and correlated to the distant metastasis of HCC. Moreover, we found that MAZ had a relationship with zinc finger E-box binding homeobox 1 and 2 (ZEB1 and ZEB2), two important mesenchymal markers in epithelial-mesenchymal transition (EMT) that were over-expressed in HCC. After knocking-down MAZ expression in HCC cell lines using RNA interruption, HCC cell proliferation, tumorigenesis, invasion and migration were significantly inhibited. In addition, we found that expression of other EMT markers was also changed besides ZEB1 and ZEB2 by decreasing MAZ expression, both detected in vivo and in vitro assays. Therefore, we conclude that MAZ can promote the invasion and metastasis of HCC by inducing EMT." @default.
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• W2551291254 date "2016-11-16" @default.
• W2551291254 modified "2023-10-17" @default.
• W2551291254 title "MYC associated zinc finger protein promotes the invasion and metastasis of hepatocellular carcinoma by inducing epithelial mesenchymal transition" @default.
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• W2551291254 doi "https://doi.org/10.18632/oncotarget.13416" @default.
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