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• W2551332065 abstract "Objective— Reasons for variations in atherosclerotic burden among individuals with similar levels of obesity are poorly understood, especially in African Americans. This study examines whether high-sensitivity C-reactive protein (hsCRP) is useful for discriminating between benign and high-risk obesity phenotypes for subclinical atherosclerosis in African Americans. Approach and Results— Participants from the Jackson Heart Study (n=4682) were stratified into 4 phenotypes based on the presence of National Heart and Lung and Blood Institute definition of obesity or obesity-equivalent (body mass index ≥30 or body mass index 25–30 with waist circumference >102 cm in men and >88 cm in women) and inflammation by hsCRP ≥2 mg/L. Using multivariate regression models, we conducted cross-sectional analyses of the association between inflammatory obesity phenotypes and subclinical atherosclerosis determined by carotid intima–media thickness or coronary artery calcium scores. Sex-specific analyses were conducted given significant interaction for gender ( P =0.03). The prevalence of obesity or equivalent was 65%, of which 30% did not have inflammation. Conversely, 37% of nonobese individuals had inflammation. Among nonobese men, hsCRP ≥2 mg/L identified a subset of individuals with higher carotid intima–media thickness (adjusted mean difference =0.05, 95% confidence interval 0.02, 0.08 mm) compared with their noninflammatory counterparts. Among obese men, hsCRP <2 mg/L identified a subset of individuals with lower coronary artery calcium compared with their inflammatory counterparts. Among women, associations between hsCRP and carotid intima–media thickness or coronary artery calcium were not found. Conclusions— In the largest African American population-based cohort to date, hsCRP was useful in identifying a subset of nonobese men with higher carotid intima–media thickness, but not in women. hsCRP did not identify a subset of obese individuals with less subclinical atherosclerosis." @default.
• W2551332065 created "2016-11-30" @default.
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• W2551332065 date "2016-12-01" @default.
• W2551332065 modified "2023-09-26" @default.
• W2551332065 title "Inflammatory Obesity Phenotypes, Gender Effects, and Subclinical Atherosclerosis in African Americans" @default.
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• W2551332065 doi "https://doi.org/10.1161/atvbaha.116.307728" @default.
• W2551332065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5121048" @default.
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