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- W2551356525 abstract "The test-negative design (TND), an epidemiologic method currently used to measure rotavirus vaccine (RV) effectiveness, compares the vaccination status of rotavirus-positive cases and rotavirus-negative controls meeting a pre-defined case definition for acute gastroenteritis. Despite the use of this study design in low-income settings, the TND has not been evaluated to measure rotavirus vaccine effectiveness.This study builds upon prior methods to evaluate the use of the TND for influenza vaccine using a randomized controlled clinical trial database. Test-negative vaccine effectiveness (VE-TND) estimates were derived from three large randomized placebo-controlled trials (RCTs) of monovalent (RV1) and pentavalent (RV5) rotavirus vaccines in sub-Saharan Africa and Asia. Derived VE-TND estimates were compared to the original RCT vaccine efficacy estimates (VE-RCTs). The core assumption of the TND (i.e., rotavirus vaccine has no effect on rotavirus-negative diarrhea) was also assessed.TND vaccine effectiveness estimates were nearly equivalent to original RCT vaccine efficacy estimates. Neither RV had a substantial effect on rotavirus-negative diarrhea.This study supports the TND as an appropriate epidemiologic study design to measure rotavirus vaccine effectiveness in low-income settings." @default.
- W2551356525 created "2016-11-30" @default.
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- W2551356525 date "2017-01-01" @default.
- W2551356525 modified "2023-09-26" @default.
- W2551356525 title "Rotavirus vaccine effectiveness in low-income settings: An evaluation of the test-negative design" @default.
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- W2551356525 doi "https://doi.org/10.1016/j.vaccine.2016.10.077" @default.
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