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- W2551383396 abstract "Background Asthma and COPD are both characterized by airflow obstruction. Subjects who have concomitant asthma and COPD may be labeled with asthma-COPD overlap syndrome (ACOS). Aim To investigate prevalence and characteristics of ACOS in a prospective population based asthma cohort. Methods Within the OLIN studies, a large adult asthma cohort (n=2,055) was identified and followed longitudinally. It includes all subjects identified, from of five population based cohorts in Sweden, as having asthma at clinical examinations at study-entry between 1986 and 2000. The last follow-up was performed in 2012-14 when 1,006 subjects participated. The examinations included a structured interview and spirometry. COPD was defined as post-bronchodilator FEV 1 /FVC Results In the asthma cohort 11% (n=233) fulfilled the criteria of ACOS at study entry, and in total 29% (n=591) fulfilled the criteria of ACOS at study entry and/or at any follow-up. The subjects with ACOS (n=591) were older at study entry than subjects with asthma without COPD (mean age 50y vs 43y, p 1 % predicted at study entry was significantly lower among those with ACOS compared to those without (76% vs 90%, p Conclusions Development of ACOS was common in this population based asthma cohort over up to 30 years of follow-up. ACOS was associated with a more severe clinical presentation compared to asthma alone. The analyses were funded by GSK." @default.
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- W2551383396 date "2016-09-01" @default.
- W2551383396 modified "2023-09-27" @default.
- W2551383396 title "The characteristics of ACOS in a population based asthma cohort" @default.
- W2551383396 doi "https://doi.org/10.1183/13993003.congress-2016.oa2004" @default.
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