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• W2551416598 endingPage "396" @default.
• W2551416598 startingPage "383" @default.
• W2551416598 abstract "The most common clinical manifestation of hepatitis A virus (HAV) infection is acute hepatitis, which typically presents with rapid onset of nausea, loss of appetite, fever, abdominal pain, dark urine, and jaundice. Importantly, HAV causes only acute hepatitis, and long-term persistent infection has never been well documented or clearly associated with chronic liver disease. The internal ribosome entry site (IRES) structure is unique, but overall resembles the aphthovirus IRES more than the enterovirus IRES. Importantly, the HAV IRES is distinguished from other picornaviral IRES elements by its apparent requirement for all eukaryotic translation initiation factors, including intact eIF- 4G, to direct internal entry of the 40S ribosome on the viral RNA. In vivo, the virus is thought to replicate primarily within hepatocytes. The infecting HAV particle presumably arrives at the basolateral membrane surface of the hepatocyte, within the space of Disse, via the portal circulation from the intestines and diffusion through the hepatic sinusoids. Viremia is present throughout much of the incubation period and into the acute phase of illness but is reduced in magnitude (as is the fecal shedding of virus) with the onset of hepatitis and the appearance of antibodies to HAV." @default.
• W2551416598 created "2016-11-30" @default.
• W2551416598 creator A5026233059 @default.
• W2551416598 creator A5048009538 @default.
• W2551416598 date "2014-04-30" @default.
• W2551416598 modified "2023-09-26" @default.
• W2551416598 title "Hepatitis A Virus" @default.
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