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- W2551444668 endingPage "5591" @default.
- W2551444668 startingPage "5578" @default.
- W2551444668 abstract "Increased mammographic density (MD) has been shown beyond doubt to be a marker for increased breast cancer risk, though the underpinning pathobiology is yet to be fully elucidated. Estrogenic activity exerts a strong influence over MD, which consequently has been observed to change predictably in response to tamoxifen anti-estrogen therapy, although results for other selective estrogen receptor modulators and aromatase inhibitors are less consistent. In both primary and secondary prevention settings, tamoxifen-associated MD changes correlate with successful modulation of risk or outcome, particularly among pre-menopausal women; an observation that supports the potential use of MD change as a surrogate marker where short-term MD changes reflect longer-term anti-estrogen efficacy. Here we summarize endocrine therapy-induced MD changes and attendant outcomes and discuss both the need for outcome surrogates in such therapy, as well as make a case for MD as such a monitoring marker. We then discuss the process and steps required to validate and introduce MD into practice as a predictor or surrogate for endocrine therapy efficacy in preventive and adjuvant breast cancer treatment settings." @default.
- W2551444668 created "2016-11-30" @default.
- W2551444668 creator A5004957581 @default.
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- W2551444668 creator A5071232249 @default.
- W2551444668 creator A5085620047 @default.
- W2551444668 date "2016-11-21" @default.
- W2551444668 modified "2023-10-10" @default.
- W2551444668 title "Mammographic density: a potential monitoring biomarker for adjuvant and preventative breast cancer endocrine therapies" @default.
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