Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551445835> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2551445835 abstract "Background Interleukin-35 (IL-35) is a newly described heterodimeric cytokine that belongs to the IL-12 family and consists of p35 (IL-12a) and EBI3 (IL-27b) subunits. IL-35 exerts immunomodulatory activities in several autoimmune inflammatory diseases. Objectives The aim of this study was to assess IL-35 expression in muscle tissue of patients with idiopathic inflammatory myopathies (IIM) and to compare serum levels of IL-35 in patients with IIM to healthy controls and asses potential association with activity of IIM. Methods The expression of IL-35 was studied in a series of 19 muscle biopsy samples of idiopathic inflammatory myopathies (9 dermatomyositis, 10 polymyositis) and 10 non-inflammatory control muscle biopsies from patients with myasthenia gravis.Serum levels of IL-35 were measured in 23 PM, 28 DM and 15 cancer associated myositis patients as well as in 40 healthy controls.Disease activity was evaluated by the Myositis Disease Activity Assessment Tool (MYOACT) and by serum muscle enzymes. Results Both IL-35 subunits were found in immune cells of the inflammatory infiltrates in IIM muscle biopsies, no immunoreactivity was observed in muscle tissue of control patients.IL-35 serum levels were increased in all IIM patients compared to healthy controls (p Conclusions IL-35 subunits are overexpressed in inflammatory infiltrates in muscle tissue of IIM patients and elevated circulating IL-35 levels correlate with several disease activity parameters. These data suggest potential role of IL-35 in the pathogenesis of inflammatory myopathies. Acknowledgement Supported by MHCR support for conceptual development of a research organization (023728) and BTCure (115142–2). Disclosure of Interest None declared" @default.
- W2551445835 created "2016-11-30" @default.
- W2551445835 creator A5006308968 @default.
- W2551445835 creator A5010887266 @default.
- W2551445835 creator A5019763858 @default.
- W2551445835 creator A5031588644 @default.
- W2551445835 creator A5040096657 @default.
- W2551445835 creator A5050451117 @default.
- W2551445835 creator A5079921904 @default.
- W2551445835 creator A5083527114 @default.
- W2551445835 date "2016-06-01" @default.
- W2551445835 modified "2023-10-13" @default.
- W2551445835 title "AB0599 Interleukin-35 in Idiopathic Inflammatory Myopathies" @default.
- W2551445835 doi "https://doi.org/10.1136/annrheumdis-2016-eular.3675" @default.
- W2551445835 hasPublicationYear "2016" @default.
- W2551445835 type Work @default.
- W2551445835 sameAs 2551445835 @default.
- W2551445835 citedByCount "0" @default.
- W2551445835 crossrefType "journal-article" @default.
- W2551445835 hasAuthorship W2551445835A5006308968 @default.
- W2551445835 hasAuthorship W2551445835A5010887266 @default.
- W2551445835 hasAuthorship W2551445835A5019763858 @default.
- W2551445835 hasAuthorship W2551445835A5031588644 @default.
- W2551445835 hasAuthorship W2551445835A5040096657 @default.
- W2551445835 hasAuthorship W2551445835A5050451117 @default.
- W2551445835 hasAuthorship W2551445835A5079921904 @default.
- W2551445835 hasAuthorship W2551445835A5083527114 @default.
- W2551445835 hasConcept C126322002 @default.
- W2551445835 hasConcept C142724271 @default.
- W2551445835 hasConcept C203014093 @default.
- W2551445835 hasConcept C2775934546 @default.
- W2551445835 hasConcept C2776914184 @default.
- W2551445835 hasConcept C2778514504 @default.
- W2551445835 hasConcept C2778690821 @default.
- W2551445835 hasConcept C2778751314 @default.
- W2551445835 hasConcept C2779387793 @default.
- W2551445835 hasConcept C2779999465 @default.
- W2551445835 hasConcept C2780942790 @default.
- W2551445835 hasConcept C2781232998 @default.
- W2551445835 hasConcept C71924100 @default.
- W2551445835 hasConcept C74172505 @default.
- W2551445835 hasConceptScore W2551445835C126322002 @default.
- W2551445835 hasConceptScore W2551445835C142724271 @default.
- W2551445835 hasConceptScore W2551445835C203014093 @default.
- W2551445835 hasConceptScore W2551445835C2775934546 @default.
- W2551445835 hasConceptScore W2551445835C2776914184 @default.
- W2551445835 hasConceptScore W2551445835C2778514504 @default.
- W2551445835 hasConceptScore W2551445835C2778690821 @default.
- W2551445835 hasConceptScore W2551445835C2778751314 @default.
- W2551445835 hasConceptScore W2551445835C2779387793 @default.
- W2551445835 hasConceptScore W2551445835C2779999465 @default.
- W2551445835 hasConceptScore W2551445835C2780942790 @default.
- W2551445835 hasConceptScore W2551445835C2781232998 @default.
- W2551445835 hasConceptScore W2551445835C71924100 @default.
- W2551445835 hasConceptScore W2551445835C74172505 @default.
- W2551445835 hasLocation W25514458351 @default.
- W2551445835 hasOpenAccess W2551445835 @default.
- W2551445835 hasPrimaryLocation W25514458351 @default.
- W2551445835 hasRelatedWork W1531753336 @default.
- W2551445835 hasRelatedWork W2043666554 @default.
- W2551445835 hasRelatedWork W2048468332 @default.
- W2551445835 hasRelatedWork W2120964544 @default.
- W2551445835 hasRelatedWork W2134836702 @default.
- W2551445835 hasRelatedWork W2136413765 @default.
- W2551445835 hasRelatedWork W2150770169 @default.
- W2551445835 hasRelatedWork W2160801251 @default.
- W2551445835 hasRelatedWork W2208616274 @default.
- W2551445835 hasRelatedWork W2313833789 @default.
- W2551445835 hasRelatedWork W2331796652 @default.
- W2551445835 hasRelatedWork W2417224848 @default.
- W2551445835 hasRelatedWork W2560414833 @default.
- W2551445835 hasRelatedWork W2739844093 @default.
- W2551445835 hasRelatedWork W2743249165 @default.
- W2551445835 hasRelatedWork W2788425799 @default.
- W2551445835 hasRelatedWork W2904547547 @default.
- W2551445835 hasRelatedWork W3096336171 @default.
- W2551445835 hasRelatedWork W3097491598 @default.
- W2551445835 hasRelatedWork W3212332387 @default.
- W2551445835 isParatext "false" @default.
- W2551445835 isRetracted "false" @default.
- W2551445835 magId "2551445835" @default.
- W2551445835 workType "article" @default.