Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551454550> ?p ?o ?g. }
- W2551454550 endingPage "288" @default.
- W2551454550 startingPage "281" @default.
- W2551454550 abstract "Epithelial cell adhesion molecule (EpCAM) is a marker for circulating tumor cells (CTCs) in various types of cancer, while cluster of differentiation 44 (CD44) is a marker for gastric cancer (GC) stem cells. To evaluate the clinical significance of CD44+ CTCs in patients with GC in the present study, the number of EpCAM+CD44+ and EpCAM+CD44‑ cells were detected in the peripheral blood of 26 GC patients and 12 healthy volunteers using flow cytometry. The number (mean ± standard deviation) of EpCAM+CD44+ cells in the GC patients and healthy volunteers was 69.9±52.0 and 0.91±2.10, respectively (P=0.0001), while that of EpCAM+CD44‑ cells was 59.1±88.0 and 9.83±9.91, respectively (P=0.0313). The sensitivity and specificity of EpCAM+CD44+ cell detection for the identification of GC patients were 92.3 and 100%, respectively. By contrast, the values of EpCAM+CD44‑ cell detection were 76.9 and 83.3%, respectively. The number of EpCAM+CD44+ cells in the GC patients was correlated with the disease stage (P=0.0423), the depth of the tumor (P=0.0314) and venous invasion (P=0.0184) in the resected tumor specimens, while the number of EpCAM+CD44‑ cells did not correlate with any clinicopathological factors. The number of EpCAM+CD44+ cells significantly decreased following surgical resection of the tumor or induction of systemic chemotherapy. Additionally, atypical cells with a high nuclear to cytoplasmic ratio were morphologically detected in the sorted EpCAM+CD44+ cells. These results suggested that CD44+ CTCs, but not CD44‑ CTCs, reflect the malignant status of the primary tumor in patients with GC, providing a candidate biomarker for diagnosis and treatment response." @default.
- W2551454550 created "2016-11-30" @default.
- W2551454550 creator A5010011336 @default.
- W2551454550 creator A5043482117 @default.
- W2551454550 creator A5044811999 @default.
- W2551454550 creator A5069582801 @default.
- W2551454550 creator A5072087361 @default.
- W2551454550 creator A5078111213 @default.
- W2551454550 creator A5084577675 @default.
- W2551454550 date "2016-11-24" @default.
- W2551454550 modified "2023-10-12" @default.
- W2551454550 title "Circulating tumor cells expressing cancer stem cell marker CD44 as a diagnostic biomarker in patients with gastric cancer" @default.
- W2551454550 cites W1438018833 @default.
- W2551454550 cites W1571158533 @default.
- W2551454550 cites W1979061512 @default.
- W2551454550 cites W1981989535 @default.
- W2551454550 cites W1985748412 @default.
- W2551454550 cites W1991852370 @default.
- W2551454550 cites W1993416658 @default.
- W2551454550 cites W1994236074 @default.
- W2551454550 cites W1996454955 @default.
- W2551454550 cites W2003533730 @default.
- W2551454550 cites W2014482710 @default.
- W2551454550 cites W2015923819 @default.
- W2551454550 cites W2016693266 @default.
- W2551454550 cites W2019607817 @default.
- W2551454550 cites W2024196852 @default.
- W2551454550 cites W2024520801 @default.
- W2551454550 cites W2044702943 @default.
- W2551454550 cites W2046848157 @default.
- W2551454550 cites W2051463368 @default.
- W2551454550 cites W2051572649 @default.
- W2551454550 cites W2052139810 @default.
- W2551454550 cites W2065522886 @default.
- W2551454550 cites W2076043395 @default.
- W2551454550 cites W2102085111 @default.
- W2551454550 cites W2107018120 @default.
- W2551454550 cites W2111976640 @default.
- W2551454550 cites W2116849106 @default.
- W2551454550 cites W2117206813 @default.
- W2551454550 cites W2126236874 @default.
- W2551454550 cites W2141384174 @default.
- W2551454550 cites W2148703808 @default.
- W2551454550 cites W2148998801 @default.
- W2551454550 cites W2152499476 @default.
- W2551454550 cites W2153011144 @default.
- W2551454550 cites W2155377949 @default.
- W2551454550 cites W2155621286 @default.
- W2551454550 cites W2168165734 @default.
- W2551454550 cites W2171298396 @default.
- W2551454550 cites W2171424524 @default.
- W2551454550 cites W2298489830 @default.
- W2551454550 cites W2319631462 @default.
- W2551454550 cites W2397433777 @default.
- W2551454550 cites W2422406283 @default.
- W2551454550 cites W2440409417 @default.
- W2551454550 cites W303784676 @default.
- W2551454550 cites W59660670 @default.
- W2551454550 doi "https://doi.org/10.3892/ol.2016.5432" @default.
- W2551454550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5244869" @default.
- W2551454550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28123556" @default.
- W2551454550 hasPublicationYear "2016" @default.
- W2551454550 type Work @default.
- W2551454550 sameAs 2551454550 @default.
- W2551454550 citedByCount "30" @default.
- W2551454550 countsByYear W25514545502017 @default.
- W2551454550 countsByYear W25514545502018 @default.
- W2551454550 countsByYear W25514545502019 @default.
- W2551454550 countsByYear W25514545502020 @default.
- W2551454550 countsByYear W25514545502021 @default.
- W2551454550 countsByYear W25514545502022 @default.
- W2551454550 countsByYear W25514545502023 @default.
- W2551454550 crossrefType "journal-article" @default.
- W2551454550 hasAuthorship W2551454550A5010011336 @default.
- W2551454550 hasAuthorship W2551454550A5043482117 @default.
- W2551454550 hasAuthorship W2551454550A5044811999 @default.
- W2551454550 hasAuthorship W2551454550A5069582801 @default.
- W2551454550 hasAuthorship W2551454550A5072087361 @default.
- W2551454550 hasAuthorship W2551454550A5078111213 @default.
- W2551454550 hasAuthorship W2551454550A5084577675 @default.
- W2551454550 hasBestOaLocation W25514545501 @default.
- W2551454550 hasConcept C121608353 @default.
- W2551454550 hasConcept C126322002 @default.
- W2551454550 hasConcept C136302470 @default.
- W2551454550 hasConcept C142724271 @default.
- W2551454550 hasConcept C1491633281 @default.
- W2551454550 hasConcept C203014093 @default.
- W2551454550 hasConcept C2776677690 @default.
- W2551454550 hasConcept C2779013556 @default.
- W2551454550 hasConcept C2780932548 @default.
- W2551454550 hasConcept C40722700 @default.
- W2551454550 hasConcept C502942594 @default.
- W2551454550 hasConcept C54355233 @default.
- W2551454550 hasConcept C553184892 @default.
- W2551454550 hasConcept C55427017 @default.
- W2551454550 hasConcept C61238886 @default.
- W2551454550 hasConcept C71924100 @default.
- W2551454550 hasConcept C86803240 @default.