Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551488900> ?p ?o ?g. }
- W2551488900 endingPage "395" @default.
- W2551488900 startingPage "381" @default.
- W2551488900 abstract "Mitochondrial function is critical to maintain high rates of oxidative metabolism supporting energy demands of both spontaneous and evoked neuronal activity in the brain. Mitochondria not only regulate energy metabolism, but also influence neuronal signaling. Regulation of “energy metabolism” and “neuronal signaling” (i.e. neurometabolic coupling), which are coupled rather than independent can be understood through mitochondria’s integrative functions of calcium ion (Ca 2+ ) uptake and cycling. While mitochondrial Ca 2+ do not affect hemodynamics directly, neuronal activity changes are mechanistically linked to functional hyperemic responses (i.e. neurovascular coupling). Early in vitro studies lay the foundation of mitochondrial Ca 2+ homeostasis and its functional roles within cells. However, recent in vivo approaches indicate mitochondrial Ca 2+ homeostasis as maintained by the role of mitochondrial Ca 2+ uniporter (mCU) influences system-level brain activity as measured by a variety of techniques. Based on earlier evidence of subcellular cytoplasmic Ca 2+ microdomains and cellular bioenergetic states, a mechanistic model of Ca 2+ mobilization is presented to understand systems-level neurovascular and neurometabolic coupling. This integrated view from molecular and cellular to the systems level, where mCU plays a major role in mitochondrial and cellular Ca 2+ homeostasis, may explain the wide range of activation-induced coupling across neuronal activity, hemodynamic, and metabolic responses." @default.
- W2551488900 created "2016-11-30" @default.
- W2551488900 creator A5034747786 @default.
- W2551488900 date "2016-11-24" @default.
- W2551488900 modified "2023-09-26" @default.
- W2551488900 title "Mitochondrial calcium homeostasis: Implications for neurovascular and neurometabolic coupling" @default.
- W2551488900 cites W1238243504 @default.
- W2551488900 cites W1485627882 @default.
- W2551488900 cites W1487350256 @default.
- W2551488900 cites W1498522163 @default.
- W2551488900 cites W150246076 @default.
- W2551488900 cites W1521077143 @default.
- W2551488900 cites W1546087257 @default.
- W2551488900 cites W1598578622 @default.
- W2551488900 cites W1834962687 @default.
- W2551488900 cites W1839705883 @default.
- W2551488900 cites W1887905189 @default.
- W2551488900 cites W1932887968 @default.
- W2551488900 cites W1935060748 @default.
- W2551488900 cites W1959238069 @default.
- W2551488900 cites W1963643075 @default.
- W2551488900 cites W1966846060 @default.
- W2551488900 cites W1967009686 @default.
- W2551488900 cites W1968789295 @default.
- W2551488900 cites W1969635562 @default.
- W2551488900 cites W1969709153 @default.
- W2551488900 cites W1970695058 @default.
- W2551488900 cites W1971125401 @default.
- W2551488900 cites W1971285535 @default.
- W2551488900 cites W1972925133 @default.
- W2551488900 cites W1973783515 @default.
- W2551488900 cites W1978582104 @default.
- W2551488900 cites W1979240985 @default.
- W2551488900 cites W1983104966 @default.
- W2551488900 cites W1985450720 @default.
- W2551488900 cites W1985730861 @default.
- W2551488900 cites W1986387796 @default.
- W2551488900 cites W1989553730 @default.
- W2551488900 cites W1992347253 @default.
- W2551488900 cites W1993696187 @default.
- W2551488900 cites W1994156254 @default.
- W2551488900 cites W1994543975 @default.
- W2551488900 cites W1994655859 @default.
- W2551488900 cites W1995605620 @default.
- W2551488900 cites W1998373886 @default.
- W2551488900 cites W2000101415 @default.
- W2551488900 cites W2000867410 @default.
- W2551488900 cites W2002660165 @default.
- W2551488900 cites W2003470377 @default.
- W2551488900 cites W2004159036 @default.
- W2551488900 cites W2004976934 @default.
- W2551488900 cites W2005266832 @default.
- W2551488900 cites W2005641666 @default.
- W2551488900 cites W2008960958 @default.
- W2551488900 cites W2009494091 @default.
- W2551488900 cites W2011551406 @default.
- W2551488900 cites W2012901741 @default.
- W2551488900 cites W2013517836 @default.
- W2551488900 cites W2016424988 @default.
- W2551488900 cites W2018039955 @default.
- W2551488900 cites W2018431813 @default.
- W2551488900 cites W2018836612 @default.
- W2551488900 cites W2020206028 @default.
- W2551488900 cites W2020395016 @default.
- W2551488900 cites W2020922795 @default.
- W2551488900 cites W2021496866 @default.
- W2551488900 cites W2022828509 @default.
- W2551488900 cites W2022908550 @default.
- W2551488900 cites W2027180565 @default.
- W2551488900 cites W2027671847 @default.
- W2551488900 cites W2027896786 @default.
- W2551488900 cites W2030286287 @default.
- W2551488900 cites W2031480757 @default.
- W2551488900 cites W2033018188 @default.
- W2551488900 cites W2034862605 @default.
- W2551488900 cites W2036909884 @default.
- W2551488900 cites W2036915958 @default.
- W2551488900 cites W2038784579 @default.
- W2551488900 cites W2039600625 @default.
- W2551488900 cites W2039848901 @default.
- W2551488900 cites W2040027002 @default.
- W2551488900 cites W2041352209 @default.
- W2551488900 cites W2046196975 @default.
- W2551488900 cites W2046806927 @default.
- W2551488900 cites W2047046337 @default.
- W2551488900 cites W2049584237 @default.
- W2551488900 cites W2049733733 @default.
- W2551488900 cites W2050517132 @default.
- W2551488900 cites W2050717100 @default.
- W2551488900 cites W2052812301 @default.
- W2551488900 cites W2052889947 @default.
- W2551488900 cites W2054078634 @default.
- W2551488900 cites W2054831378 @default.
- W2551488900 cites W2057803801 @default.
- W2551488900 cites W2060039512 @default.
- W2551488900 cites W2060319077 @default.
- W2551488900 cites W2062135485 @default.
- W2551488900 cites W2063093203 @default.