Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551498027> ?p ?o ?g. }
- W2551498027 endingPage "132" @default.
- W2551498027 startingPage "121" @default.
- W2551498027 abstract "During the last two decades, septic encephalopathy (SE) was recognized as a clinically relevant problem with a high prevalence in patients at admission and during their hospital stay. SE is a condition associated with increased mortality and morbidity such as long-term cognitive impairment. Areas covered: This review illustrates the pathophysiology of sepsis-associated encephalopathy and encephalitis involving blood-brain-barrier dysfunction and neuroinflammation caused by endothelial and microglial activation by endogenous or pathogen-derived compounds, hypoxia by impaired microvascular regulation and septic shock as well as imbalance of neurotransmitters. The continuum between septic-embolic and septic-metastatic encephalitis and SE is underlined by histological findings. The options of technical examinations and biomarkers to diagnose SE are discussed together with established therapeutic options as well as current experimental approaches. Expert commentary: An outlook for clinicians is provided including promising diagnostic approaches by means of new imaging techniques. Clinical trials with drugs already established for other indications such as statins, erythropoietin and minocycline are warranted in the future." @default.
- W2551498027 created "2016-11-30" @default.
- W2551498027 creator A5006000088 @default.
- W2551498027 creator A5020139224 @default.
- W2551498027 creator A5021202090 @default.
- W2551498027 creator A5051117448 @default.
- W2551498027 date "2016-12-05" @default.
- W2551498027 modified "2023-10-16" @default.
- W2551498027 title "Septic encephalopathy and septic encephalitis" @default.
- W2551498027 cites W13341289 @default.
- W2551498027 cites W143661867 @default.
- W2551498027 cites W149381565 @default.
- W2551498027 cites W1541590313 @default.
- W2551498027 cites W1559226045 @default.
- W2551498027 cites W156539719 @default.
- W2551498027 cites W1571481062 @default.
- W2551498027 cites W1717808310 @default.
- W2551498027 cites W1836567906 @default.
- W2551498027 cites W1852293756 @default.
- W2551498027 cites W1926496310 @default.
- W2551498027 cites W1960154697 @default.
- W2551498027 cites W1965291001 @default.
- W2551498027 cites W1967712727 @default.
- W2551498027 cites W1970635860 @default.
- W2551498027 cites W1970943114 @default.
- W2551498027 cites W1973050315 @default.
- W2551498027 cites W1975137099 @default.
- W2551498027 cites W1977180762 @default.
- W2551498027 cites W1977905350 @default.
- W2551498027 cites W1982458288 @default.
- W2551498027 cites W1986892052 @default.
- W2551498027 cites W1987536543 @default.
- W2551498027 cites W1987688434 @default.
- W2551498027 cites W1989063324 @default.
- W2551498027 cites W1993864865 @default.
- W2551498027 cites W1995321663 @default.
- W2551498027 cites W1996631284 @default.
- W2551498027 cites W2002390864 @default.
- W2551498027 cites W2004284087 @default.
- W2551498027 cites W2004967267 @default.
- W2551498027 cites W2012739682 @default.
- W2551498027 cites W2015167181 @default.
- W2551498027 cites W2021506741 @default.
- W2551498027 cites W2023299675 @default.
- W2551498027 cites W2023830686 @default.
- W2551498027 cites W2026710900 @default.
- W2551498027 cites W2027792306 @default.
- W2551498027 cites W2029512625 @default.
- W2551498027 cites W2034682340 @default.
- W2551498027 cites W2037159410 @default.
- W2551498027 cites W2039489324 @default.
- W2551498027 cites W2040290877 @default.
- W2551498027 cites W2042306666 @default.
- W2551498027 cites W2042956469 @default.
- W2551498027 cites W2047549421 @default.
- W2551498027 cites W2047869397 @default.
- W2551498027 cites W2048359313 @default.
- W2551498027 cites W2049927822 @default.
- W2551498027 cites W2053189438 @default.
- W2551498027 cites W2053371666 @default.
- W2551498027 cites W2053684366 @default.
- W2551498027 cites W2056908273 @default.
- W2551498027 cites W2057979643 @default.
- W2551498027 cites W2061207287 @default.
- W2551498027 cites W2065269562 @default.
- W2551498027 cites W2065678433 @default.
- W2551498027 cites W2068200074 @default.
- W2551498027 cites W2072400349 @default.
- W2551498027 cites W2073316020 @default.
- W2551498027 cites W2076143217 @default.
- W2551498027 cites W2077220204 @default.
- W2551498027 cites W2080320137 @default.
- W2551498027 cites W2081655354 @default.
- W2551498027 cites W2082445194 @default.
- W2551498027 cites W2082868348 @default.
- W2551498027 cites W2086015715 @default.
- W2551498027 cites W2087578679 @default.
- W2551498027 cites W2091180729 @default.
- W2551498027 cites W2094068467 @default.
- W2551498027 cites W2098572294 @default.
- W2551498027 cites W2103186044 @default.
- W2551498027 cites W2103374346 @default.
- W2551498027 cites W2109005423 @default.
- W2551498027 cites W2110686105 @default.
- W2551498027 cites W2111642569 @default.
- W2551498027 cites W2114563054 @default.
- W2551498027 cites W2115633980 @default.
- W2551498027 cites W2116423522 @default.
- W2551498027 cites W2121391159 @default.
- W2551498027 cites W2123903144 @default.
- W2551498027 cites W2125313769 @default.
- W2551498027 cites W2127723018 @default.
- W2551498027 cites W2128111962 @default.
- W2551498027 cites W2128249288 @default.
- W2551498027 cites W2130271602 @default.
- W2551498027 cites W2131901811 @default.
- W2551498027 cites W2132940371 @default.
- W2551498027 cites W2134535009 @default.