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- W2551519986 abstract "Ewing's sarcoma (ES) and primitive neuroecto- dermal tumor (PNET) are members of a tumor family con- sistently associated with chromosomal translocation and functional fusion of the EWS gene to any of several structur- ally related transcription factor genes. Similar gene fusion events occur in other mesenchymal and hematopoietic tu- mors and are tumor-specific. The resulting novel transcrip- tion factor-like chimeric proteins are believed to contribute to tumor biology by aberrant regulation of gene expression altering critical controls of cell proliferation and differentia- tion. These tumor-specific molecular rearrangements are useful for primary diagnosis, may provide prognostic infor- mation, and present potential therapeutic targets. The re- cent advances in our understanding of the molecular biol- ogy of ES and PNET represent a paradigm for the application of the basic biology of neoplasia to clinical man- agement of patients. J Clin Oncol 18:204-213. © 2000 by American Society of Clinical Oncology." @default.
- W2551519986 created "2016-11-30" @default.
- W2551519986 creator A5033029074 @default.
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- W2551519986 date "2000-01-01" @default.
- W2551519986 modified "2023-09-27" @default.
- W2551519986 title "Molecular B iology o f t he E wing's S arcoma/Primitiv e Neuroectodermal T umor F amily" @default.
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