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- W255153898 abstract "Abstract Calorie restriction extends the span of laboratory animals, and now scientists are beginning to discover the molecular basis for this phenomenon. The findings so far indicate that there are that respond to stressors (like calorie restriction) by turning on cell survival mechanisms. Outright skeptics of calorie restriction argue that the practice will not work in humans, while those more dubious contend that if the practice works at all, the addition of time to the span will be minimal compared with the sacrifices endured by adhering to such a rigid dietary regimen. In fact, several studies have indicated that those classified as overweight (according to body mass index) have at least as low a risk of premature death as those of normal weight, and despite the obesity epidemic in the United States, expectancy continues to rise. Nevertheless, the goal of scientists is to devise ways to target the newfound genes in order to achieve the alleged life-extending effects without actually restricting calories. So, does longevity depend on eating less or eating more, or maybe in the future, taking a pill? Science and society are precariously close to seeking longevity simply for longevity's sake. Where does happiness fit into the equation? Introduction That is good and preferable to death is a widely shared sentiment. It is a philosophy that makes the quest for longevity logical and sensible to most people. Arguably, there are probably few who would not choose to extend precious time with friends and family. What happens after death is unknown and somewhat frightening to contemplate. Even if faith dictates a blissful and contented afterlife, there is sorrow and sadness when someone dies. To want to prolong seems only natural, but where does the pursuit appropriately end? At what point are science and society seeking longevity simply for longevity's sake, just to see if it can be done? Are lives that are longer somehow better than those that are shorter? Is it a symbol of status to live long? Are people that live longer also happier, and is it worth it if they are not? Do longevity and happiness depend on one another, or are they independent? It is not surprising that longevity and ways to achieve it are subjects of intense research and speculation, because of the widespread human contention that living longer is worth the effort. Consequently, there are reports of and recommendations for strategies that are purported to extend the human span beyond what is normally expected. However, in today's age of instant food, instant gratification and instant information, the very term life becomes problematic, and the pursuit of longevity falls victim to the same must-have-it-now and must-have-it-all mentality prevalent in so many other aspects of society, creating the new oxymoron instantaneous longevity. Long term strategies, if not quickly circumvented by shortcuts, invariably fail. What's more, building a of happiness is often left completely out of the equation, as if it is beside the point and has nothing to do with either the quality or quantity of life. Perhaps it is assumed that longevity begets happiness. Armed with the attitude that longevity is something for which to strive, consumers are barraged with messages touting ways to go about achieving it, even if happiness is forsaken in the process. After all, should the journey toward longevity become uncomfortable, there is always a shortcut. This paper examines a strategy that has the potential to enhance longevity, and even delay age-related disease symptoms. Even though scientific evidence is still confusing and contradictory, plans for future shortcuts are plentiful. Calorie restriction has been shown in numerous organisms, including mammals, to extend the of lab animals significantly. (1[1],2[2],3[3]) Physiological parameters associated with age-related chronic diseases, such as diabetes, cancer, arthritis and cardiovascular disease, are improved by calorie restricted diets in lower organisms and mammals, including rats, mice and humans. …" @default.
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- W255153898 date "2006-09-22" @default.
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- W255153898 title "Calories and Longevity: Do They Really Matter?" @default.
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