FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551544186> ?p ?o ?g. }

• W2551544186 endingPage "1193" @default.
• W2551544186 startingPage "1183" @default.
• W2551544186 abstract "A novel modified nucleic acid nanoparticle harboring an annexin A2 aptamer for ovarian cancer cell targeting and a GC rich sequence for doxorubicin loading is designed and constructed. The system utilizes a highly stable three-way junction (3WJ) motif from phi29 packaging RNA as a core structure. A phosphorothioate-modified DNA aptamer targeting annexin A2, Endo28, was conjugated to one arm of the 3WJ. The pRNA-3WJ motif retains correct folding of attached aptamer, keeping its functions intact. It is of significant utility for aptamer-mediated targeted delivery. The DNA/RNA hybrid nanoparticles remained intact after systemic injection in mice and strongly bound to tumors with little accumulation in healthy organs 6 h post-injection. The Endo28-3WJ-Sph1/Dox intercalates selectively enhanced toxicity to annexin A2 positive ovarian cancer cells in vitro. The constructed RNA/DNA hybrid nanoparticles can potentially enhance the therapeutic efficiency of doxorubicin at low doses for ovarian cancer treatment through annexin A2 targeted drug delivery." @default.
• W2551544186 created "2016-11-30" @default.
• W2551544186 creator A5003759585 @default.
• W2551544186 creator A5018903804 @default.
• W2551544186 creator A5020081483 @default.
• W2551544186 creator A5041350339 @default.
• W2551544186 creator A5065859286 @default.
• W2551544186 creator A5069765017 @default.
• W2551544186 creator A5080554776 @default.
• W2551544186 date "2017-04-01" @default.
• W2551544186 modified "2023-10-12" @default.
• W2551544186 title "RNA nanoparticles harboring annexin A2 aptamer can target ovarian cancer for tumor-specific doxorubicin delivery" @default.
• W2551544186 cites W102375006 @default.
• W2551544186 cites W1921543583 @default.
• W2551544186 cites W1940922428 @default.
• W2551544186 cites W1969499569 @default.
• W2551544186 cites W1973509266 @default.
• W2551544186 cites W1976642063 @default.
• W2551544186 cites W1978267970 @default.
• W2551544186 cites W1985944218 @default.
• W2551544186 cites W1996517412 @default.
• W2551544186 cites W1999362080 @default.
• W2551544186 cites W2006434892 @default.
• W2551544186 cites W2032670918 @default.
• W2551544186 cites W2042063670 @default.
• W2551544186 cites W2044085417 @default.
• W2551544186 cites W2048833314 @default.
• W2551544186 cites W2053073103 @default.
• W2551544186 cites W2059990765 @default.
• W2551544186 cites W2065110263 @default.
• W2551544186 cites W2074433934 @default.
• W2551544186 cites W2089941377 @default.
• W2551544186 cites W2094082853 @default.
• W2551544186 cites W2105824455 @default.
• W2551544186 cites W2125536449 @default.
• W2551544186 cites W2141157874 @default.
• W2551544186 cites W2141928906 @default.
• W2551544186 cites W2149850403 @default.
• W2551544186 cites W2162417581 @default.
• W2551544186 cites W2168943084 @default.
• W2551544186 cites W2169961966 @default.
• W2551544186 cites W2205893844 @default.
• W2551544186 cites W2219978888 @default.
• W2551544186 cites W2224498017 @default.
• W2551544186 cites W2271834483 @default.
• W2551544186 cites W2296073154 @default.
• W2551544186 cites W2311190733 @default.
• W2551544186 cites W2311852869 @default.
• W2551544186 cites W2312566259 @default.
• W2551544186 cites W2329421426 @default.
• W2551544186 cites W2335495927 @default.
• W2551544186 cites W2336438907 @default.
• W2551544186 cites W2342410043 @default.
• W2551544186 cites W2394891736 @default.
• W2551544186 cites W2409627395 @default.
• W2551544186 cites W2411690760 @default.
• W2551544186 cites W2412058059 @default.
• W2551544186 cites W2416149247 @default.
• W2551544186 cites W2435478394 @default.
• W2551544186 cites W2464231245 @default.
• W2551544186 cites W2467548657 @default.
• W2551544186 cites W2473581795 @default.
• W2551544186 cites W2473597755 @default.
• W2551544186 cites W2515596886 @default.
• W2551544186 cites W2534038616 @default.
• W2551544186 cites W4235388735 @default.
• W2551544186 doi "https://doi.org/10.1016/j.nano.2016.11.015" @default.
• W2551544186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5426907" @default.
• W2551544186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27890659" @default.
• W2551544186 hasPublicationYear "2017" @default.
• W2551544186 type Work @default.
• W2551544186 sameAs 2551544186 @default.
• W2551544186 citedByCount "54" @default.
• W2551544186 countsByYear W25515441862017 @default.
• W2551544186 countsByYear W25515441862018 @default.
• W2551544186 countsByYear W25515441862019 @default.
• W2551544186 countsByYear W25515441862020 @default.
• W2551544186 countsByYear W25515441862021 @default.
• W2551544186 countsByYear W25515441862022 @default.
• W2551544186 countsByYear W25515441862023 @default.
• W2551544186 crossrefType "journal-article" @default.
• W2551544186 hasAuthorship W2551544186A5003759585 @default.
• W2551544186 hasAuthorship W2551544186A5018903804 @default.
• W2551544186 hasAuthorship W2551544186A5020081483 @default.
• W2551544186 hasAuthorship W2551544186A5041350339 @default.
• W2551544186 hasAuthorship W2551544186A5065859286 @default.
• W2551544186 hasAuthorship W2551544186A5069765017 @default.
• W2551544186 hasAuthorship W2551544186A5080554776 @default.
• W2551544186 hasBestOaLocation W25515441862 @default.
• W2551544186 hasConcept C104317684 @default.
• W2551544186 hasConcept C121608353 @default.
• W2551544186 hasConcept C128972844 @default.
• W2551544186 hasConcept C153911025 @default.
• W2551544186 hasConcept C178790620 @default.
• W2551544186 hasConcept C185592680 @default.
• W2551544186 hasConcept C202751555 @default.
• W2551544186 hasConcept C24107716 @default.
• W2551544186 hasConcept C2776694085 @default.

• next