FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551551229> ?p ?o ?g. }

• W2551551229 endingPage "3483" @default.
• W2551551229 startingPage "3471" @default.
• W2551551229 abstract "Awareness of the immunological underpinnings of host-parasite interactions may reveal immune signaling pathways that could be used to treat inflammatory disease in humans. Previously we showed that infection with the rat tapeworm, Hymenolepis diminuta, used as a model helminth, or systemic delivery of worm antigen (HdAg) significantly reduced the severity of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice. Extending these analyses, intraperitoneal injection of HdAg dose-dependently suppressed dextran sodium sulfate (DSS)-induced colitis, and this was paralleled by reduced gamma interferon (IFN-γ), interleukin-17 (IL-17), and tumor necrosis factor alpha (TNF-α) production and increased IL-10 production from mitogen-activated splenocytes. Treatment with HdAg resulted in a CCR2-dependent recruitment of CDllb+ F4/80+ Ly6Chi Gr-1lo monocyte-like cells into the peritoneum 24 h later that were predominantly programmed death ligand 1 (PD-L1) positive and CXCR2 negative. In vitro assays indicated that these cells were unable to suppress T cell proliferation but enhanced IL-10 and IL-4 production from activated T cells. Adoptive transfer of the HdAg-recruited monocytic cells into naive mice blocked DSS-induced colitis. These findings add to the variety of means by which treatment with parasitic helminth-derived antigens can ameliorate concomitant disease. A precise understanding of the mechanism(s) of action of HdAg and other helminth-derived antigens (and a parallel consideration of putative side effects) may lead to the development of novel therapies for human idiopathic disorders such as inflammatory bowel disease." @default.
• W2551551229 created "2016-11-30" @default.
• W2551551229 creator A5003014152 @default.
• W2551551229 creator A5010374438 @default.
• W2551551229 creator A5012123572 @default.
• W2551551229 creator A5025260970 @default.
• W2551551229 creator A5047868313 @default.
• W2551551229 creator A5050995193 @default.
• W2551551229 creator A5052314402 @default.
• W2551551229 creator A5058811797 @default.
• W2551551229 creator A5058878946 @default.
• W2551551229 creator A5069037711 @default.
• W2551551229 date "2016-12-01" @default.
• W2551551229 modified "2023-10-14" @default.
• W2551551229 title "Treatment with Cestode Parasite Antigens Results in Recruitment of CCR2 ⁺ Myeloid Cells, the Adoptive Transfer of Which Ameliorates Colitis" @default.
• W2551551229 cites W1591185269 @default.
• W2551551229 cites W1621676818 @default.
• W2551551229 cites W1640573958 @default.
• W2551551229 cites W1754156123 @default.
• W2551551229 cites W1767092522 @default.
• W2551551229 cites W1833602160 @default.
• W2551551229 cites W1853062779 @default.
• W2551551229 cites W1961330221 @default.
• W2551551229 cites W1970838369 @default.
• W2551551229 cites W1974671009 @default.
• W2551551229 cites W1982500490 @default.
• W2551551229 cites W1983831001 @default.
• W2551551229 cites W1987605367 @default.
• W2551551229 cites W1992222076 @default.
• W2551551229 cites W1993264795 @default.
• W2551551229 cites W1996589341 @default.
• W2551551229 cites W1999829139 @default.
• W2551551229 cites W2016451329 @default.
• W2551551229 cites W2024755684 @default.
• W2551551229 cites W2025953324 @default.
• W2551551229 cites W2026578487 @default.
• W2551551229 cites W2047340328 @default.
• W2551551229 cites W2047907655 @default.
• W2551551229 cites W2050860694 @default.
• W2551551229 cites W2051250007 @default.
• W2551551229 cites W2055004642 @default.
• W2551551229 cites W2057499380 @default.
• W2551551229 cites W2058036025 @default.
• W2551551229 cites W2061417157 @default.
• W2551551229 cites W2062583300 @default.
• W2551551229 cites W2063736745 @default.
• W2551551229 cites W2066301236 @default.
• W2551551229 cites W2068175785 @default.
• W2551551229 cites W2068714945 @default.
• W2551551229 cites W2069182180 @default.
• W2551551229 cites W2071022240 @default.
• W2551551229 cites W2073283130 @default.
• W2551551229 cites W2074448842 @default.
• W2551551229 cites W2082829276 @default.
• W2551551229 cites W2100476234 @default.
• W2551551229 cites W2102538857 @default.
• W2551551229 cites W2107020458 @default.
• W2551551229 cites W2112240061 @default.
• W2551551229 cites W2113743453 @default.
• W2551551229 cites W2114263798 @default.
• W2551551229 cites W2121445620 @default.
• W2551551229 cites W2122403898 @default.
• W2551551229 cites W2125582836 @default.
• W2551551229 cites W2129589060 @default.
• W2551551229 cites W2130298480 @default.
• W2551551229 cites W2134837867 @default.
• W2551551229 cites W2139117245 @default.
• W2551551229 cites W2141832186 @default.
• W2551551229 cites W2157412589 @default.
• W2551551229 cites W2162641825 @default.
• W2551551229 cites W2163716475 @default.
• W2551551229 cites W2321369117 @default.
• W2551551229 cites W2329562787 @default.
• W2551551229 cites W2338485512 @default.
• W2551551229 cites W2424946527 @default.
• W2551551229 cites W2512794614 @default.
• W2551551229 cites W26718029 @default.
• W2551551229 doi "https://doi.org/10.1128/iai.00681-16" @default.
• W2551551229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5116724" @default.
• W2551551229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27672083" @default.
• W2551551229 hasPublicationYear "2016" @default.
• W2551551229 type Work @default.
• W2551551229 sameAs 2551551229 @default.
• W2551551229 citedByCount "25" @default.
• W2551551229 countsByYear W25515512292017 @default.
• W2551551229 countsByYear W25515512292018 @default.
• W2551551229 countsByYear W25515512292019 @default.
• W2551551229 countsByYear W25515512292020 @default.
• W2551551229 countsByYear W25515512292021 @default.
• W2551551229 countsByYear W25515512292022 @default.
• W2551551229 countsByYear W25515512292023 @default.
• W2551551229 crossrefType "journal-article" @default.
• W2551551229 hasAuthorship W2551551229A5003014152 @default.
• W2551551229 hasAuthorship W2551551229A5010374438 @default.
• W2551551229 hasAuthorship W2551551229A5012123572 @default.
• W2551551229 hasAuthorship W2551551229A5025260970 @default.
• W2551551229 hasAuthorship W2551551229A5047868313 @default.
• W2551551229 hasAuthorship W2551551229A5050995193 @default.

• next