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• W2551554150 abstract "Genetic analysis in common disorders of adulthood seeks to determine whether and which genes are involved in the predisposition to the occurrence, the prognosis and the response to various forms of therapy for a condition. Broadly these analyses are divided into complementary old and new approaches and all are hampered if onset of the condition is age-related and if exclusion of the disorder is problematical. This is clearly the case for cardiovascular disease in general where the incidence is age-related and where patients with extensive atherosclerosis may remain asymptomatic. Furthermore, reflecting the general­ ised nature of the disease process, symptoms may occur at diverse sites and patients presenting with intermittent claudication will have an increased risk of coronary heart disease and stroke in addition to lower limb events (Reunanen et al. 1982). Hence this review includes data from studies of coronary heart disease and stroke as well as peripheral vascular disease to reflect genetic involvement in the predisposition to atherosclerosis in general, but also indicates clues to factors favouring site-specific disease." @default.
• W2551554150 created "2016-11-30" @default.
• W2551554150 creator A5076790614 @default.
• W2551554150 date "1991-01-01" @default.
• W2551554150 modified "2023-09-27" @default.
• W2551554150 title "23 Genetic Analysis" @default.
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• W2551554150 hasPublicationYear "1991" @default.
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