FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2551574118> ?p ?o ?g. }

• W2551574118 endingPage "e0166455" @default.
• W2551574118 startingPage "e0166455" @default.
• W2551574118 abstract "Background and Aim We performed a systematic review and meta-analysis of all the available evidence comparing efficacy and safety of oral prolonged released beclomethasone dipropionate (BDP) to active oral controls in patients with mild-to-moderate ulcerative colitis (UC). A subgroup-analysis compared the effectiveness of BDP and 5-ASA. Methods Literature research was performed in different databases, as well as manual search to identify abstracts from international meetings with data not included in extensive publications. Experts in the field and companies involved in BDP development and manufacture were contacted to identify unpublished studies used for registration purposes. Dichotomous data were pooled to obtain odds ratio meta-analysis. Results Five randomized controlled trials that compared oral BDP 5mg/day vs. all oral active controls in treating UC were identified as eligible. Efficacy and safety have been addressed after 4-week treatment period. One study evaluated efficacy and safety of BDP vs. prednisone and 4 of BDP vs. 5-ASA. Treatment with oral BDP 5 mg/day induces a significant better clinical response compared to oral 5-ASA (OR 1.86, 95% CI = 1.23–2.82, P = 0.003). The effect is detectable even when the comparison to prednisone is added (OR 1.41, 95% CI = 1.03–1.93, P = 0.03). Data on remission indicate that the potential clinical efficacy of BDP may be better than 5-ASA (OR 1.55, 95% CI = 1.00–2.40, P = 0.05). This difference is lost when the comparison with prednisone is added (OR 1.30, 95% CI = 0.76–2.23, P = 0.34). The safety analysis showed no differences between BDP and 5-ASA (OR 0.55, 95% CI = 0.24–1.27, P = 0.16). The lack of difference is maintained even when the study with prednisone is added (OR 0.67, 95% CI = 0.44–1.01, P = 0.06). However, the trend of difference is clear and indicates a more favourable safety profile of BDP compared to 5-ASA and PD. Conclusions Oral prolonged release BDP showed a superior efficacy vs. oral 5-ASA in inducing clinical improvement of mild-to-moderate UC with a similar safety profile." @default.
• W2551574118 created "2016-11-30" @default.
• W2551574118 creator A5008246913 @default.
• W2551574118 creator A5010932748 @default.
• W2551574118 creator A5015901650 @default.
• W2551574118 creator A5052702662 @default.
• W2551574118 creator A5062679235 @default.
• W2551574118 creator A5080352321 @default.
• W2551574118 date "2016-11-15" @default.
• W2551574118 modified "2023-09-26" @default.
• W2551574118 title "Efficacy and Safety of Oral Beclomethasone Dipropionate in Ulcerative Colitis: A Systematic Review and Meta-Analysis" @default.
• W2551574118 cites W109999970 @default.
• W2551574118 cites W155598629 @default.
• W2551574118 cites W1936764733 @default.
• W2551574118 cites W1963585385 @default.
• W2551574118 cites W1964307940 @default.
• W2551574118 cites W1968358910 @default.
• W2551574118 cites W1980361315 @default.
• W2551574118 cites W1985072509 @default.
• W2551574118 cites W1985687346 @default.
• W2551574118 cites W1988774893 @default.
• W2551574118 cites W1989050098 @default.
• W2551574118 cites W1990945786 @default.
• W2551574118 cites W2001671503 @default.
• W2551574118 cites W2009897953 @default.
• W2551574118 cites W2011135579 @default.
• W2551574118 cites W2013333818 @default.
• W2551574118 cites W2018223454 @default.
• W2551574118 cites W2026619451 @default.
• W2551574118 cites W2033334628 @default.
• W2551574118 cites W2040254506 @default.
• W2551574118 cites W2044883546 @default.
• W2551574118 cites W2045793320 @default.
• W2551574118 cites W2048818357 @default.
• W2551574118 cites W2053196420 @default.
• W2551574118 cites W2068208094 @default.
• W2551574118 cites W2071728199 @default.
• W2551574118 cites W2072998439 @default.
• W2551574118 cites W2078077899 @default.
• W2551574118 cites W2085405257 @default.
• W2551574118 cites W2094269361 @default.
• W2551574118 cites W2107279890 @default.
• W2551574118 cites W2116836515 @default.
• W2551574118 cites W2120522488 @default.
• W2551574118 cites W2121650731 @default.
• W2551574118 cites W2125435699 @default.
• W2551574118 cites W2134465718 @default.
• W2551574118 cites W2166930089 @default.
• W2551574118 cites W2167357745 @default.
• W2551574118 cites W2238442202 @default.
• W2551574118 cites W2345993232 @default.
• W2551574118 cites W2411236973 @default.
• W2551574118 cites W2413201923 @default.
• W2551574118 cites W2414446467 @default.
• W2551574118 cites W2416486303 @default.
• W2551574118 cites W2515281232 @default.
• W2551574118 cites W2523273596 @default.
• W2551574118 cites W2614323529 @default.
• W2551574118 cites W3022903699 @default.
• W2551574118 cites W2402008753 @default.
• W2551574118 doi "https://doi.org/10.1371/journal.pone.0166455" @default.
• W2551574118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5113024" @default.
• W2551574118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27846307" @default.
• W2551574118 hasPublicationYear "2016" @default.
• W2551574118 type Work @default.
• W2551574118 sameAs 2551574118 @default.
• W2551574118 citedByCount "23" @default.
• W2551574118 countsByYear W25515741182017 @default.
• W2551574118 countsByYear W25515741182018 @default.
• W2551574118 countsByYear W25515741182019 @default.
• W2551574118 countsByYear W25515741182020 @default.
• W2551574118 countsByYear W25515741182021 @default.
• W2551574118 countsByYear W25515741182022 @default.
• W2551574118 countsByYear W25515741182023 @default.
• W2551574118 crossrefType "journal-article" @default.
• W2551574118 hasAuthorship W2551574118A5008246913 @default.
• W2551574118 hasAuthorship W2551574118A5010932748 @default.
• W2551574118 hasAuthorship W2551574118A5015901650 @default.
• W2551574118 hasAuthorship W2551574118A5052702662 @default.
• W2551574118 hasAuthorship W2551574118A5062679235 @default.
• W2551574118 hasAuthorship W2551574118A5080352321 @default.
• W2551574118 hasBestOaLocation W25515741181 @default.
• W2551574118 hasConcept C126322002 @default.
• W2551574118 hasConcept C156957248 @default.
• W2551574118 hasConcept C168563851 @default.
• W2551574118 hasConcept C187960798 @default.
• W2551574118 hasConcept C197934379 @default.
• W2551574118 hasConcept C2778720950 @default.
• W2551574118 hasConcept C2779134260 @default.
• W2551574118 hasConcept C2780479503 @default.
• W2551574118 hasConcept C535046627 @default.
• W2551574118 hasConcept C71924100 @default.
• W2551574118 hasConcept C95190672 @default.
• W2551574118 hasConceptScore W2551574118C126322002 @default.
• W2551574118 hasConceptScore W2551574118C156957248 @default.
• W2551574118 hasConceptScore W2551574118C168563851 @default.
• W2551574118 hasConceptScore W2551574118C187960798 @default.
• W2551574118 hasConceptScore W2551574118C197934379 @default.

• next